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MetabolomicsX chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction

Statin drugs lower blood cholesterol levels for cardiovascular disease prevention. Women are more likely than men to experience adverse statin effects, particularly new-onset diabetes (NOD) and muscle weakness. Here we find that impaired glucose homeostasis and muscle weakness in statin-treated f...

2024-05-23 | MTBLS9677 | MetaboLights
TranscriptomicsEscape from X chromosome inactivation occurs within topologically associated domains
The spatial proximity between regulatory elements and their target genes has a profound affect on gene expression. X Chromosome Inactivation (XCI) is an epigenetic process by which an entire chromosome is rendered, for the most part, transcriptionally silent. A few genes are known to escape XCI and ...
ORGANISM(S): Mus musculus 
2014-03-26 | E-GEOD-49111 | biostudies-arrayexpress
GenomicsSpreading of X-chromosome inactivation via a hierarchy of defined Polycomb stations
Binding of Polycomb repressive complex 2 (PRC2) and chromatin composition of the inactive X (Xi) before, during and after X chromosome inactivation reveal that spreading is driven by a combination of Xi-specific strong and moderate Ezh2 sites. Sequence context of these sites shows a moderate enrichm...
ORGANISM(S): Mus musculus 
2012-11-01 | E-GEOD-36905 | biostudies-arrayexpress
TranscriptomicsX-chromosome inactivation in monkey embryos and pluripotent stem cells
In this study, we explored x-inactivation in monkey embryos (ICM and TE separately) and pluripotent stem cells (IVF derived ES, SCNT-derived ES and monkey iPS) To elucidate x-inactivation in experimentally reprogrammed pluripotent cells, we derived pluripotent stem cells by both SCNT and iPS approac...
ORGANISM(S): Macaca mulatta 
2012-08-31 | E-GEOD-36252 | biostudies-arrayexpress
TranscriptomicsX-inactivation in hESCs
X chromosome inactivation (XCI) is a dosage compensation mechanism in female cells to regulate X-linked gene expression. We report here that subcultures from established lines of female hESCs displayed variations (0-100%) in the expression of XCI markers such as XIST RNA coating and enrichment of h...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-9637 | biostudies-arrayexpress
GenomicsSmchd1 dependent and independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome.
X chromosome inactivation involves multiple levels of chromatin modification, established progressively and in a stepwise manner during early development. The chromosomal protein Smchd1 has recently been shown to play an important role in DNA methylation of CpG islands (CGIs), a late step in the X i...
ORGANISM(S): Mus musculus 
2012-10-15 | E-GEOD-37333 | biostudies-arrayexpress
TranscriptomicsSpatial organisation of the X inactivation center
We report the application of Chromosome Conformation Capture Carbon-copy (5C) to a 4.5 Mb stretch of the mouse X chromosome encompassing the X inactivation center locus. We uncover a series of discrete 200kb-1Mb topologically associating domains (TADs). These align with several domain-wide epigenomi...
ORGANISM(S): Mus musculus 
2012-04-11 | E-GEOD-35721 | biostudies-arrayexpress
TranscriptomicsIncomplete X-inactivation initiated by a hypomorphic Xist allele in the mouse
Mammals have evolved a mechanism to compensate for the difference in the number of X chromosome genes between XX females and XY males by inactivating one of the two X chromosomes in females. This X chromosome inactivation phenomenon is triggered by Xist gene, which is essential for X-inactivation to...
ORGANISM(S): Mus musculus 
2011-03-30 | E-GEOD-27373 | biostudies-arrayexpress
GenomicsX-chromosome dynamics revealed by the RNA interactome and chromosomal binding of CTCF
CTCF is a master regulator that plays a role in genome architecture and gene expression. A key aspect of CTCF’s mechanism involves bringing together distant genetic elements for intra- and inter-chromosomal interactions. Evidence from epigenetic processes, such as X-chromosome inactivation (XCI), su...
ORGANISM(S): Mus musculus 
2015-01-09 | E-GEOD-58242 | biostudies-arrayexpress
TranscriptomicsHigh-resolution chromosomal maps of Xist RNA reveal a two-step spreading mechanism during X-inactivation
The Xist long noncoding RNA (lncRNA) is essential for X-chromosome inactivation (XCI), the process by which mammals compensate for unequal numbers of sex chromosomes. During XCI, Xist coats the future inactive X (Xi) and recruits Polycomb Repressive Complex 2 (PRC2) to the X-inactivation center (Xic...
ORGANISM(S): Mus musculus 
2013-11-04 | E-GEOD-48649 | biostudies-arrayexpress
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