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TranscriptomicsEscape from X chromosome inactivation occurs within topologically associated domains
The spatial proximity between regulatory elements and their target genes has a profound affect on gene expression. X Chromosome Inactivation (XCI) is an epigenetic process by which an entire chromosome is rendered, for the most part, transcriptionally silent. A few genes are known to escape XCI and ...
ORGANISM(S): Mus musculus 
2014-03-26 | E-GEOD-49111 | biostudies-arrayexpress
GenomicsSpreading of X-chromosome inactivation via a hierarchy of defined Polycomb stations
Binding of Polycomb repressive complex 2 (PRC2) and chromatin composition of the inactive X (Xi) before, during and after X chromosome inactivation reveal that spreading is driven by a combination of Xi-specific strong and moderate Ezh2 sites. Sequence context of these sites shows a moderate enrichm...
ORGANISM(S): Mus musculus 
2012-11-01 | E-GEOD-36905 | biostudies-arrayexpress
TranscriptomicsX-chromosome inactivation in monkey embryos and pluripotent stem cells
In this study, we explored x-inactivation in monkey embryos (ICM and TE separately) and pluripotent stem cells (IVF derived ES, SCNT-derived ES and monkey iPS) To elucidate x-inactivation in experimentally reprogrammed pluripotent cells, we derived pluripotent stem cells by both SCNT and iPS approac...
ORGANISM(S): Macaca mulatta 
2012-08-31 | E-GEOD-36252 | biostudies-arrayexpress
TranscriptomicsHigh-resolution chromosomal maps of Xist RNA reveal a two-step spreading mechanism during X-inactivation
The Xist long noncoding RNA (lncRNA) is essential for X-chromosome inactivation (XCI), the process by which mammals compensate for unequal numbers of sex chromosomes. During XCI, Xist coats the future inactive X (Xi) and recruits Polycomb Repressive Complex 2 (PRC2) to the X-inactivation center (Xic...
ORGANISM(S): Mus musculus 
2013-11-04 | E-GEOD-48649 | biostudies-arrayexpress
TranscriptomicsX-inactivation in hESCs
X chromosome inactivation (XCI) is a dosage compensation mechanism in female cells to regulate X-linked gene expression. We report here that subcultures from established lines of female hESCs displayed variations (0-100%) in the expression of XCI markers such as XIST RNA coating and enrichment of h...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-9637 | biostudies-arrayexpress
GenomicsX-chromosome dynamics revealed by the RNA interactome and chromosomal binding of CTCF
CTCF is a master regulator that plays a role in genome architecture and gene expression. A key aspect of CTCF’s mechanism involves bringing together distant genetic elements for intra- and inter-chromosomal interactions. Evidence from epigenetic processes, such as X-chromosome inactivation (XCI), su...
ORGANISM(S): Mus musculus 
2015-01-09 | E-GEOD-58242 | biostudies-arrayexpress
ProteomicsSPEN is a molecular integrator that bridges Xist with transcriptional and epigenetic control of X-chromosome inactivation
Xist represents a paradigm for long non-coding RNA function in epigenetic regulation, although how it mediates X-chromosome inactivation (XCI) remains largely unexplained. Multiple Xist-RNA binding proteins have recently been identified, including SPEN/SHARP, whose knockdown has been associated with...
ORGANISM(S): Mus musculus (Mouse) 
2021-04-19 | PXD015699 | Pride
Xci X-chromosome inactivation Epigenetic Xist Spen 
ProteomicsThe role of early chromatin changes in X chromosome inactivation
During development, transcriptional and chromatin modification changes co-occur but the order and causality of events often remain unclear. We explore the interrelationship of these processes using the paradigm of X-chromosome inactivation (XCI). We initiate XCI in female, mouse embryonic stem cells...
ORGANISM(S): Mus musculus (Mouse) 
2019-01-17 | PXD011344 | Pride
X chromosome inactivation  mouse embryonic stem cells  epigenomics  transcriptomics  histone deacetylation  polycomb  histone acetylation 
ProteomicsSegmental X-chromosome monosomies are compensated by transcriptional upregulation.
XX mice undergo both X-chromosome inactivation (XCI) and X-chromosome upregulation (XCU) to balance X-linked gene dosage with autosomes and XY mice. XCU has also been reported in XY cells, as well as cells with a single copy of the X-chromosome (XO). The two dosage compensation processes have been s...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-19 | PXD057399 | Pride
X-chromosome upregulation (xcu) Transcription X-chromosome X-chromosome inactivation (xci) 
GenomicsDerivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations
The presence of two active X chromosomes (XaXa) is a hallmark of the ground state of pluripotency specific to murine embryonic stem cells (ESCs). Human ESCs invariably exhibit signs of X chromosome inactivation (XCI) and are considered developmentally more advanced than their murine counterparts. W...
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-21141 | biostudies-arrayexpress
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