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UnknownEvolution of the "Internet Plus Health Care" Mode Enabled by Artificial Intelligence: Development and Application of an Outpatient Triage System.

Background

Although new technologies have increased the efficiency and convenience of medical care, patients still struggle to identify specialized outpatient departments in Chinese tertiary hospitals due to a lack of medical knowledge.

Objective

The objective of our study was to deve...
S-EPMC11561436 | biostudies-literature
UnknownClinical and genetic characteristics of 42 Chinese paediatric patients with X-linked adrenal hypoplasia congenita.

Background

X-linked adrenal hypoplasia congenita (AHC) is a rare disorder characterized by primary adrenal insufficiency (PAI) and hypogonadotropic hypogonadism (HH), with limited clinical and genetic characterization.

Methods

The clinical, biochemical, genetic, therapeutic, and follo...
S-EPMC10214642 | biostudies-literature
UnknownFarnesoid X Receptor Agonist Tropifexor Improves Intestinal Defense Response and Epithelial Barrier Function in Neonatal Piglets Receiving Parenteral Nutrition.
Long-term parenteral nutrition (PN) can lead to liver and intestinal injury in neonates, but effective prevention strategies are limited. Our previous research demonstrated that activation of farnesoid X receptor (FXR) signaling with tropifexor (TXR) could mitigate PN-induced liver damage in neonata...
S-EPMC12502888 | biostudies-literature
ProteomicsEvaluation of therapeutic effects of tetramethylpyrazine nitrone in Alzheimer’s disease mouse model and proteomics analysis
The pathophysiology of Alzheimer’s disease (AD) is multifactorial with characteristic extracellular accumulation of amyloid-beta (Aβ) and intraneuronal aggregation of hyperphosphorylated tau in the brain. Development of disease-modifying treatment for AD has been challenging. Recent studies suggest ...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD039514 | Pride
Amyloid beta Alzheimer’s disease Pink1. Tetramethylpyrazine nitrone Proteomic analysis 
ProteomicsHippocampal proteomic alteration in triple transgenic mouse model of Alzheimer’s disease: insights into the role of PINK 1 proteins in donepezil treatment Hippocampal proteomic alteration in triple transgenic mouse model of Alzheimer’s disease: insights into the role of PINK 1 proteins in donepezil treatment
Donepezil, an acetylcholinesterase (AChE) inhibitor, was approved by FDA for the symptomatic therapies of patients with Alzheimer’s disease (AD) in 1996. Although donepezil have been regarded as the standard and first-line treatment for AD, the capacity of such drugs to alter the underlying disease ...
ORGANISM(S): Mus musculus (Mouse) 
2018-12-03 | PXD010604 | Pride
Alzheimer’s disease (ad) Amyloid beta (aβ) Donepezil Proteomics Pink1 
ProteomicsProteomic profiling of hippocampus and cerebral cortex in triple-transgenic mouse model of Alzheimer’s disease: Alterations with memantine treatment, part 2
INTRODUCTION Alzheimer’s disease (AD) is an advanced neurodegenerative disorder characterized by progressive impairment in both memory loss and cognitive capacities, which resulting in severe dementia [1]. The pathogenesis of AD is complicated and poorly understood. According to the World Alzheimer ...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-12 | PXD012110 | Pride
Memantine (mem) Alzheimer’s disease (ad) Proteomics 
UnknownThe LysoPS/GPR174 axis drives metastatic progression in esophageal squamous cell carcinoma through cAMP-PKA-CREB signaling activation.

Background

Esophageal squamous cell carcinoma (ESCC) is a highly lethal malignancy with a 5-year survival rate of less than 20%, largely due to its high propensity for metastasis and recurrence. There is an urgent need to identify targeted therapeutic agents for this disease. While lysophosp...
S-EPMC11995483 | biostudies-literature
UnknownLncRNA RP11-465B22.8 triggers esophageal cancer progression by targeting miR-765/KLK4 axis.
LncRNAs play an important role in tumorigenesis and progression; however, the function and mechanisms of lncRNAs in esophageal cancer (EC) remain largely unclear. In this study, we screened the differentially expressed lncRNAs in EC by using RNA-seq and one of the most upregulated lncRNAs, lncRNA RP...
S-EPMC8463694 | biostudies-literature
UnknownFeasibility and safety of computed tomography-guided intrapulmonary injection of indocyanine green for localization of peripheral pulmonary ground-glass nodules.

Background

The early surgical intervention for pulmonary ground-glass nodules (GGNs) has become increasingly important, but accurate identification of these nodules during thoracoscopic surgery poses challenges due to the need for sublobar resections and reliance on visual and tactile percep...
S-EPMC10585534 | biostudies-literature
UnknownAtorvastatin Induces Mitochondria-Dependent Ferroptosis via the Modulation of Nrf2-xCT/GPx4 Axis.
As one of the cornerstones of clinical cardiovascular disease treatment, statins have an extensive range of applications. However, statins commonly used have side reactions, especially muscle-related symptoms (SAMS), such as muscle weakness, pain, cramps, and severe condition of rhabdomyolysis. This...
S-EPMC8927716 | biostudies-literature
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