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MetabolomicsCD73 inhibitor AB680 suppresses glioblastoma in mice by inhibiting purine metabolism and promoting P2RY12<sup>+</sup> microglia transformation.
CD73 (ecto-5'-nucleotidase) is a metabolic immune checkpoint that dephosphorylates AMP to produce adenosine. Adenosine plays a pivotal role in immunosuppressive tumor microenvironment (TME) through adenosine receptors expressed on various immune cells. AB680, a specific CD73 inhibitor, is currently ...
2025-08-04 | MTBLS11084 | MetaboLights
ProteomicsCDH11 regulates presynaptic vesicle trafficking and neuronal activity in autism-related brain circuit
The molecular etiology of numerous risk genes for autism spectrum disorder (ASD), including CDH11, remains elusive. We investigated the role of CDH11 in the development of ASD-related behaviors using gene-deficient mice. CDH11 is enriched at synapses in glutamatergic neurons of the anterior cingulat...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-08 | PXD056411 | Pride
Synaptic adhesion Asd Neuronal activity Proteomics Brain circuit Self-grooming Cdh11 Acc 
ProteomicsCDH11 regulates presynaptic vesicle trafficking and neuronal activity in autism-related brain circuit
The molecular etiology of numerous risk genes for autism spectrum disorder (ASD), including CDH11, remains elusive. We investigated the role of CDH11 in the development of ASD-related behaviors using gene-deficient mice. CDH11 is enriched at synapses in glutamatergic neurons of the anterior cingulat...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-08 | PXD056074 | Pride
Synaptic adhesion Asd Neuronal activity Proteomics Brain circuit Self-grooming Cdh11 Acc 
ProteomicsCDH11 regulates presynaptic vesicle trafficking and neuronal activity in autism-related brain circuit
The molecular etiology of numerous risk genes for autism spectrum disorder (ASD), including CDH11, remains elusive. We investigated the role of CDH11 in the development of ASD-related behaviors using gene-deficient mice. CDH11 is enriched at synapses in glutamatergic neurons of the anterior cingulat...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-08 | PXD055834 | Pride
Synaptic adhesion Asd Neuronal activity Proteomics Brain circuit Self-grooming Cdh11 Acc 
UnknownRecombinant mannan-binding lectin magnetic beads increase pathogen detection in immunocompromised patients.
Not available
S-EPMC10838228 | biostudies-literature
UnknownUnveiling correlations between aristolochic acids and liver cancer: spatiotemporal heterogeneity phenomenon.
Not available
S-EPMC11439320 | biostudies-literature
UnknownIntegration of Transcriptomic and Metabolomic Data to Compare the Hepatotoxicity of Neonatal and Adult Mice Exposed to Aristolochic Acid I.
Not available
S-EPMC8992794 | biostudies-literature
ProteomicsComprehensive genome editing and signaling pathway engineering evolve potent and safe adenoviral producer cell
Dramatic attention has been drawn to adenovirus as a vehicle for vaccine and cancer therapy, due to the capabilities of annihilating tumor cells and stimulating host immune response. However, few producer cells are perfect for adenoviral manufacture. Herein, a novel genome editing strategy by CRISPR...
ORGANISM(S): Homo Sapiens 
2025-10-21 | PXD069719 |
MetabolomicsGNPS - 15_fungal isolates_bioconversion_EGCG
Dark teas are prepared by a microbial fermentation process. Flavan-3-ol B-ring fission analogues (FBRFAs) are some of the key bioactive constituents that characterise dark teas. The microbes and biosynthetic precursors involved in the formation of FBRFAs are not known. Using a unique solid-state fer...
ORGANISM(S): Trametes Hirsuta (ncbitaxon:5327) Cladosporium Sp. (ncbitaxon:1707700) Cladosporium Tenuissimum (ncbitaxon:70808) Aspergillus Niger (ncbitaxon:5061) Eurotium Cristatum (ncbitaxon:41421) Candida Metapsilosis (ncbitaxon:273372) Penicillium Steckii (ncbitaxon:303698) Penicillium Oxalicum (ncbitaxon:69781) Aspergillus Sp. (ncbitaxon:5065) Bjerkandera Adusta (ncbitaxon:5331) Aspergillus Ochraceus (ncbitaxon:40380) Penicillium Sp. (ncbitaxon:5081) 
2020-05-02 | MSV000085360 | GNPS
ProteomicsMorphological change of gill and activation of cell phagocytosis pathway through differential proteomics in Mytilus coruscus under starvation
Mytilus coruscus are one of the dominant shellfish in the Yangtze estuary, but they often face food deprivation due to seasonal fluctuations in algal abundance caused by seasonal freshwater flushing and high-density aquaculture. To investigate the coping strategies of M. coruscus to starvation stres...
ORGANISM(S): Mytilus Coruscus 
2023-03-16 | PXD040908 |
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