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ProteomicsCoupled protein synthesis and ribosome-guided piRNA processing on mRNAs
PIWI-interacting small RNAs (piRNAs) protect the germline genome and are essential for fertility. Previously, we showed that ribosomes guide the biogenesis of piRNAs from long non-coding RNAs (lncRNAs) after translating the short open reading frames (ORFs) near their 5′ cap. It remained unclear, how...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-17 | PXD027489 | Pride
Mouse Protein synthesis Pirna Mrna Testis Lc-ms/ms 
ProteomicsVCP enhances autophagy-related osteosarcoma progression by recruiting USP2 to inhibit ubiquitination and degradation of FASN
The mass spectrometry data were acquired using a Q Exactive HF mass spectrometer coupled with an UltiMate 3000 RSLCnano liquid chromatography system. Peptide samples were dissolved in a loading buffer, introduced via an autosampler, and separated on an analytical column (75 μm × 25 cm, C18, 1.9 μm, ...
ORGANISM(S): Homo Sapiens 
PXD055763 |
ProteomicsUSP3 promotes osteosarcoma progression via deubiquitinating EPHA2 and activating the PI3K/AKT signaling pathway
Knock down the expression level of USP3 in osteosarcoma cell 143B and observe the proteins with altered ubiquitination levels.
ORGANISM(S): Homo Sapiens 
2024-02-20 | PXD049717 |
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