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ProteomicsSystematic mutagenesis of TFIIH subunit p52/Tfb2 identifies residues required for XPB/Ssl2 subunit function and genetic interactions with TFB6
TFIIH is an evolutionarily conserved complex that plays central roles in both RNA polymerase II (pol II) transcription and DNA repair. As an integral component of the pol II Pre-Initiation Complex (PIC), TFIIH regulates pol II enzyme activity in numerous ways. The TFIIH subunit XPB/Ssl2 is an ATP-de...
ORGANISM(S): Homo sapiens (Human) 
2022-09-07 | PXD036107 | Pride
Tfiih p52/tfb2 xpb/ssl2 tfb6 
ProteomicsSystematic mutagenesis identifies p52/Tfb2 residues required for XPB/Ssl2 function within TFIIH and genetic interactions with TFB6
TFIIH is an evolutionarily conserved complex that plays central roles in both RNA polymerase II (pol II) transcription and DNA repair. As an integral component of the pol II Pre-Initiation Complex (PIC), TFIIH regulates the activity of the pol II enzyme in numerous ways. The TFIIH subunit XPB/Ssl2 i...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-03-11 | PXD035576 | Pride
Mutagenesis Integrity Transcription start site Function P52/tfb2 Structure Rna polymerase ii transcription Gtf2h4 General transcription factor tfiih Tfb6 Xpb/ssl2 
GenomicsSystematic mutagenesis identifies p52/Tfb2 residues required for XPB/Ssl2 function within TFIIH and genetic interactions with TFB6
Systematic mutagenesis identifies p52/Tfb2 residues required for XPB/Ssl2 function within TFIIH and genetic interactions with TFB6
PRJNA803201 | ENA
TranscriptomicsSystematic mutagenesis identifies p52/Tfb2 residues required for XPB/Ssl2 function within TFIIH and genetic interactions with TFB6
TFIIH is an evolutionarily conserved complex that plays central roles in both RNA polymerase II (pol II) transcription and DNA repair. As an integral component of the pol II Pre-Initiation Complex, TFIIH regulates the activity of the pol II enzyme in numerous ways. One of the essential functions of ...
ORGANISM(S): Saccharomyces cerevisiae 
2022-06-30 | GSE196069 | GEO
UnknownSystematic mutagenesis of TFIIH subunit p52/Tfb2 identifies residues required for XPB/Ssl2 subunit function and genetic interactions with TFB6.
Not available
S-EPMC9557730 | biostudies-literature
UnknownMechanism of start site selection by RNA polymerase II: interplay between TFIIB and Ssl2/XPB helicase subunit of TFIIH.
Not available
S-EPMC3249109 | biostudies-literature
UnknownThe Role of XPB/Ssl2 dsDNA Translocase Processivity in Transcription Start-site Scanning.
Not available
S-EPMC8327364 | biostudies-literature
UnknownArchitecture of the RNA polymerase II preinitiation complex and mechanism of ATP-dependent promoter opening.
Not available
S-EPMC3414687 | biostudies-literature
UnknownSsl2/TFIIH function in transcription start site scanning by RNA polymerase II in Saccharomyces cerevisiae.
Not available
S-EPMC8589449 | biostudies-literature
UnknownTFIIH generates a six-base-pair open complex during RNAP II transcription initiation and start-site scanning.
Not available
S-EPMC5741190 | biostudies-literature
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