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TranscriptomicsExpression data in PD-L1 positive and PD-L1 negative human melanoma samples
Blocking the PD-1/PD-L1 immunosuppressive pathway has shown promise in the treatment of certain cancers including melanoma. This study investigates differences in the gene expression profiles of human melanomas that do or do not display the immunosuppressive protein PD-L1. Further understanding of g...
ORGANISM(S): Homo sapiens 
2015-05-01 | E-GEOD-65041 | biostudies-arrayexpress
ProteomicsPptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis
Mitochondrial proteins are replete with phosphorylation; however, the origin, abundance, and functional relevance of these modifications are largely unclear. Nonetheless, mitochondria possess multiple resident phosphatases, suggesting that protein dephosphorylation may be broadly important for mitoc...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-29 | PXD012743 | Pride
Mitochondia Pptc7 Phosphoproteome 
TranscriptomicsExpression data in human renal cell carcinoma samples from patients who did or did not respond to anti-PD-1 (Nivolumab) immunotherapy
Pre-treatment tumor expression of PD-L1 has been shown to correlate with favorable clinical outcomes following PD-1 blocking therapies. However, the majority of patients with PD-L1+ tumors do not respond to treatment. With the goal of obtaining insights into the mechanisms underlying the response to...
ORGANISM(S): Homo sapiens 
2016-08-04 | E-GEOD-67501 | biostudies-arrayexpress
TranscriptomicsExpression data of germinating Arabidopsis seeds
In depth temporal profiling of transcript changes at 10 time points during germination in Arabidopsis seed was carried out. The time course utilised, encompassed seed maturation, stratification, germination and post-germination and provided a global investigation into the tightly regulated, phasic c...
ORGANISM(S): Arabidopsis thaliana 
2011-09-08 | E-GEOD-30223 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD4+ memory T cells reveals they are preferential targets for bystander activation and apoptosis
There is much evidence that T cells may be activated via mechanisms which act independently of direct TCR ligation. Despite this, the question of whether such forms of ‘bystander’ T cell activation occur during immune responses is hotly debated. To address some outstanding questions, we set up ...
ORGANISM(S): Homo sapiens 
2009-02-21 | E-GEOD-13738 | biostudies-arrayexpress
MetabolomicsTargeting the SREBP-dependent lipidomic reprogramming by virus infection for broad-spectrum therapeutic intervention
Viruses are obligate intracellular parasites that exploit the host metabolic machineries to meet their extraordinary biosynthetic demands. Integrative transcriptomic and lipidomic profiling confirmed that Middle East respiratory syndrome coronavirus (MERS-CoV) infection reprograms the host lipid met...
2018-11-26 | MTBLS762 | MetaboLights
UnknownA role of histone H3 lysine 4 methyltransferase components in endosomal trafficking
Not available
S-JCBD-200902146 | bioimages
UnknownGenome-wide association study of paclitaxel and carboplatin disposition in women with epithelial ovarian cancer.
Not available
S-EPMC5784122 | biostudies-literature
GenomicsModeling Fanconi Anemia pathogenesis and therapeutics using integration-free patient iPSCs
To elucidate the transcriptional and epigenetic alterations underlying the neurogenic defects of FA-NSCs, we conducted gene expression microarray analysis and global DNA methylation profiling. The gene expression pattern of gene-corrected NSCs (C-FA-NSCs) resembled that of control-NSCs but clustered...
ORGANISM(S): Homo sapiens 
2014-05-15 | E-GEOD-57685 | biostudies-arrayexpress
TranscriptomicsMouse Expression DB 2001 CHMC
Expression profiles of different mouse tissue samples profiles.
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-2178 | biostudies-arrayexpress
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