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MetabolomicsAcupuncture Synergized With Bortezomib Improves Survival of Multiple Myeloma Mice via Decreasing Metabolic Ornithine
Multiple myeloma (MM) is a hematological malignancy worldwide in urgent need for novel therapeutic strategies. Since Velcade (bortezomib) was approved for the treatment of relapsed/refractory MM in 2003, we have seen considerable improvement in extending MM patient survival. However, most patients a...
2022-02-21 | MTBLS3487 | MetaboLights
TranscriptomicsInsights into the invasiveness of triple negative breast cancer from genome-wide profiling of transcription factor AP-1 (expression)
Triple negative breast cancer (TNBC) is an aggressive clinical phenotype, and accounts for 15% to 20% of all breast cancers. The molecular determinants of malignant cell behaviors in TNBC remain largely unknown. We find that the AP-1 transcription factor component, Fra-1, is overexpressed in basal-l...
ORGANISM(S): Homo sapiens 
2014-06-30 | E-GEOD-46440 | biostudies-arrayexpress
UnknownInsights into the invasiveness of triple negative breast cancer from genome-wide profiling of transcription factor AP-1 (expression)
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-46440 | biostudies-other
TranscriptomicsSlr0643, a S2P Homolog, Is Essential for Acid Acclimation in Cyanobacterium Synechocystis sp. PCC 6803
Every cyanobacterial species contains gene encoding site-2-protease (S2P) homolog. The studied prokaryotic S2P homologs play essential roles in regulating stress response through intramembrane proteolysis of membrane-bound anti-sigma factors. Here, gene of Slr0643, one of four S2P homologs in Synech...
ORGANISM(S): Synechocystis sp. PCC 6803 
2012-09-18 | E-GEOD-37747 | biostudies-arrayexpress
ProteomicsProteogenomic Characterization Reveals Tumorigenesis and Progression of Lung Adenocarcinoma Manifested as Subsolid Nodules
Lung adenocarcinoma (LUAD) radiologically displayed as subsolid nodules (SSNs) is prevalent. However, precise clinical management of SSNs requires thorough understanding of its tumorigenesis and progression. Here, we analyzed 66 LUAD displayed as SSNs covering 3 histological stages including adenoca...
ORGANISM(S): Homo sapiens (Human) 
2025-02-10 | PXD046637 | Pride
Lung adenocarcinoma  proteomic Phosphoproteomic  glycoproteomic 
ProteomicsStreptococcus suis SC-19, LC-MSMS
Phosphoproteomic analysis to identify deregulated phosphoproteins in stk mutant strain compared to the parental wild type strain SC-19
ORGANISM(S): Streptococcus suis 
2017-03-27 | PXD005663 | Pride
Streptococcus suis sc-19 Lc-msms 
TranscriptomicsInsights into the proliferation and invasiveness of breast cancer from genome-wide profiling of estrogen receptor beta 2
The human ERβ variant, ERβ2, is expressed at higher levels than ERβ1 in many breast cancer cell lines and breast tumours and increasing evidence supports the hypothesis that ERβ2, in contrast to ERβ1, is associated with aggressive phenotypes of various cancers. We identified a breast cancer cell lin...
ORGANISM(S): Homo sapiens 
2015-05-01 | E-GEOD-57379 | biostudies-arrayexpress
ProteomicsQuantitative Pattern of hPTMs by Mass Spectrometry-based Proteomics with Implications for Triple-Negative Breast Cancer
Triple-negative breast cancer (TNBC) is characterized by its aggressive behavior, with trend to early relapse and metastasis as well as poor survival. Limited therapies and lack of effective therapeutic targets are one of the main challenges in clinical management of TNBC. Histone post-translationa...
ORGANISM(S): Homo Sapiens 
2024-02-01 | PXD049101 |
UnknownE3 Ubiquitin Ligase CHIP Facilitates cAMP and cGMP Signalling Cross-talk by Polyubiquitinating PDE9A
Not available
S-SCDT-10_1038-S44318-024-00351-7 | biostudies-other
ProteomicsLithocholic acid targets TULP3-Sirtuins to deacetylate v-ATPase and activate AMPK
Lithocholic acid (LCA), accumulated in mammals during calorie restriction (CR), can activate AMP-activated protein kinase (AMPK) and slow down ageing1. However, how LCA is signalled to activate AMPK and elicit the biological effects is unclear. Here, we show that LCA can enhance the activity of sirt...
ORGANISM(S): Homo Sapiens Mus Musculus 
2024-09-16 | PXD056134 |
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