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UnknownMulti-omics investigation of metabolic dysregulation in depression: integrating metabolomics, weighted gene co-expression network analysis, and mendelian randomization
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S-EPMC12378940 | biostudies-literature
MetabolomicsMetabolomic Profiling of Mice Serum during Toxoplasmosis Progression Using Liquid Chromatography-Mass Spectrometry
Better understanding of the molecular changes associated with disease is essential for identifying new routes to improved therapeutics and diagnostic tests. The aim of this study was to investigate the dynamic changes in the metabolic profile of mouse sera during T. gondii infection. We carried out ...
2017-01-25 | MTBLS216 | MetaboLights
ProteomicsProteomic characterization of the colorectal cancer response to chemoradiation and targeted therapies
Herein, we assembled a cohort composed of 254 CRC patients, including discovery cohort (N = 124) and validation cohort (N = 130), which received either chemotherapy (mainly FOLFOX therapy), chemoradiotherapy (mainly FOLFOX combined with radiotherapy), or targeted combination therapy (mainly FOLFOX c...
ORGANISM(S): Homo Sapiens 
2023-10-30 | PXD046566 |
ProteomicsProteogenomic Landscape of Breast Ductal Carcinoma Reveals Tumor Progression Characteristics and Therapeutic Targets
In this study, we performed integrated multi-omics analyses using genomic (n = 79), transcriptomic (n = 42), proteomic (n = 224), and phosphoproteomic (n = 49) data collected from 224 samples from 168 patients with malignant and benign breast diseases. Our data revealed the characteristics of the li...
ORGANISM(S): Homo Sapiens 
2024-08-02 | PXD040750 |
ProteomicsProteogenomics of urothelial bladder cancer progression reveals the distinguished molecular features of different pathological subtypes
We reported a comprehensive proteogenomics analysis, including whole-genome sequencing, RNA sequencing, and proteomics and phosphoproteomics profiling, of 448 trace-tumor-samples from 190 urothelial bladder neoplasm patients, covering the whole spectrum of disease stages and grades. DNA damage was a...
ORGANISM(S): Homo Sapiens 
2023-08-02 | PXD043775 |
ProteomicsProteogenomic Characterization of Skull-base Chordoma
Skull-base chordoma (SBC) is a rare, aggressive bone cancer with a high recurrent rate. Genomic studies of SBC have improved our understanding of the disease’s biology. However, the molecular biological characteristics and the effective therapy of SBC remain unknown. Here, we carried out an integrat...
ORGANISM(S): Homo Sapiens 
2024-07-01 | PXD053550 |
ProteomicsProteogenomic landscape of the Esophageal Squamous Cell Cancer reveals the lipid droplet formation process as a novel therapeutic target
The integrated proteogenomic analysis revealed proteomic characteristics associated with genomic variants and clinical features including arm or focal amplifications, SNV mutations, tumor size, lymph node metastasis, smoking history.
ORGANISM(S): Homo Sapiens 
2025-03-24 | PXD062163 |
ProteomicsProteogenomic landscape of clear cell renal cell carcinoma response to tyrosine kinase inhibitor
We performed proteomic analysis of 115 ccRCC patients samples undergoing sunitinib treatment.
ORGANISM(S): Homo Sapiens 
2023-06-08 | PXD042844 |
ProteomicsProteogenomic Characterization of MiT Family Translocation Renal Cell Carcinoma
Comprehensive proteogenomic analysis of Microphthalmia Transcription Factor (MiT) family translocation renal cell carcinoma (tRCC) tumor and normal adjacent tissues was performed to elucidate the molecular landscape of these tumors.
ORGANISM(S): Homo Sapiens 
2022-07-20 | PXD035377 |
ProteomicsIntegrative Proteogenomic Characterization of Early Esophageal Cancer
A comprehensive proteogenomic analysis of 786 trace-tumor-samples from 154 esophageal cancers, covering all 9 major histopathology stages and 22 substages via pathological dissection.
ORGANISM(S): Homo Sapiens 
2022-12-20 | PXD038961 |
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