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MetabolomicsMetabolomic Profiling of the Striatum in Shank3 Knockout ASD Rats: Effects of Early Swimming Regulation

OBJECTIVE: This study aimed to investigate the regulatory impact of early swimming intervention on striatal metabolism in Shank3 gene knockout ASD model rats.

METHODS: Shank3 gene knockout exon 11-21 male 8-day-old SD rats were used as experimental subject...

2024-09-27 | MTBLS8577 | MetaboLights
ProteomicsProteomic analysis of the aggregated proteins in cerebral vessles from MYPT1SMKO mice
To comprehensively understand the mechanism by which MYPT1 modulates the phenotypic switching of VSMCs after ischemic stroke, the proteins of cortical small vessel from MYPT1SMKO and WT mice subjected to MCAO or sham group were collected for proteomic screening.
ORGANISM(S): Mus musculus (Mouse) 
2021-08-21 | PXD027869 | Pride
Mypt1 Ischemmic stroke Vsmc Bbb 
ProteomicsProtein phosphorylation and N-glycosylation in the early stage of Spiroplasma eriocheiris infect Eriocheir sinensis
As a novel lethal pathogen of Eriocheirsinensistremor disease,Spiroplasma eriocheiris, has led into catastrophic economic losses in aquaculture.The hemocytes of E. sinensis is the first target cells of S. eriocheiris. Our study is the first time designed to understanding of the phosphoproteome and N...
ORGANISM(S): Eriocheir sinensis (Chinese mitten crab) 
2026-04-27 | PXD014116 | Pride
Phosphoproteome Eriocheir sinensis N-glycoproteome Spiroplasma eriocheiris Hemocytes 
ProteomicsHuman cholangiocarcinoma LC-MS/MS
The glycosylation landscape of Human cholangiocarcinoma (CCA), and how it affects CCA diagnosis and prognosis, has recently emerged as an appealing research field.In this study, we used chemical glycoproteomic analysis Click-iG for systematic profiling of intact glycopeptides in CCA and HIBEpiC cell...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD048188 | Pride
Glycoproteomics Click-ig Cholangiocarcinoma 
MetabolomicsRespectM revealed metabolic heterogeneity powers deep learning for reshaping the DBTL cycle

Synthetic biology, relying on Design-Build-Test-Learn (DBTL) cycle, aims to solve medicine, manufacturing and agriculture problems. However, the DBTL cycle’s Learn (L) step lacks predictive power for the behavior of biological systems, resulting from the incompatibility between sparse testing dat...

2023-06-29 | MTBLS3830 | MetaboLights
ProteomicsProteomic Insights into Rice Protein Palmitoylation and Its Role in Cytosolic Translation
Protein palmitoylation, also known as S-acylation, is a reversible post-translational modification in which fatty acids are covalently attached to cysteine residues via thioester bonds. To date, protein palmitoylation has been well studied in animal cells, where it plays a crucial role in regulating...
ORGANISM(S): Oryza sativa (Rice) 
2026-02-13 | PXD060133 | Pride
Rice ribo-seq  palmitoylation  translation 
MetabolomicsDynamic metabolic and transcriptomic profiling reveals the biosynthetic characteristics of hydroxycinnamic acid amides (HCAAs) in sunflower pollen

Sunflower pollen is a natural nutritious food with a long history and multiple functions, however, the main chemical components apart from flavonoids and their biosynthesis processes have not been thoroughly investigated. In this study, seven hydroxycinnamic acid amides (HCAAs) (1-7) abundant in ...

2021-10-15 | MTBLS3075 | MetaboLights
MetabolomicsGut microbiota production of trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy
Numerous studies found intestinal microbiota alterations which are thought to affect the development of various diseases through the production of gut-derived metabolites. However, the specific metabolites and their pathophysiological contribution to cardiac hypertrophy or heart failure progression ...
2021-12-08 | MTBLS3174 | MetaboLights
UnknownMolecular Simulation Elaborating the Mechanism of 1β-Hydroxy Alantolactone Inhibiting Ubiquitin-Conjugating Enzyme UbcH5s.
Not available
S-EPMC6954291 | biostudies-literature
ProteomicsQuantitative Proteomics Reveals Dormancy Related Proteins Mediated Attenuation Program in Mycobacterium Strain
To better understand the virulence difference among different MTB strains and identify new targets for therapeutic intervention under hypoxia condition, we compared the global protein expression at the protein level by quantitative proteomics among H37Rv, H37Ra and BCG.
ORGANISM(S): Mycobacterium tuberculosis Mycobacterium tuberculosis complex 
2022-04-01 | PXD017174 | Pride
Mycobacterium tuberculosis Tmt Virulence，quantitative proteomic 
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