Sort   by:  
 Page size 
ProteomicsRBIS regulates ribosome biogenesis to affect progression in lung adenocarcinoma
Transient overexpress RBIS and control plasmid in H293T cells and collect cells after 48 hours, then performed IP assays using anti-Flag beads subjected samples to LC-MSMS to screen proteins interacting with RBIS.
ORGANISM(S): Homo Sapiens 
2024-10-23 | PXD057090 |
ProteomicsLow-dose metformin targets the lysosome-AMPK pathway through PEN2
Metformin is the most prescribed anti-diabetic medicine, and has also been shown to have other various benefits, such as anti-aging and anti-cancer effects. For clinical doses of metformin, it is known that AMPK plays a major role; however, the direct molecular target of metformin remains unclear. H...
ORGANISM(S): Homo Sapiens Mus Musculus 
2021-12-01 | PXD030090 |
ProteomicsAMPK targets PDZD8 to promote carbon source shift to glutamine
This project contains the raw MS data that identified PDZD8 as a substrate of AMPK on the MAM of ER-mitochondria contact. They also revealed that site T527 is an AMPK-phosphorylation site.
ORGANISM(S): Mus Musculus 
2023-04-06 | PXD041428 |
ProteomicsLow glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate
This project identified the interacting proteins of p53 under glucose starvation in HEK293 cells.
ORGANISM(S): Homo Sapiens 
2023-04-04 | PXD041361 |
ProteomicsThe aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK
The activity of 5’-adenosine monophosphate-activated protein kinase (AMPK) is inversely correlated with the cellular availability of glucose. When glucose levels are low, the glycolytic enzyme aldolase is not bound to fructose-1,6-bisphosphate (FBP) and, instead, signals to activate lysosomal AMPK. ...
ORGANISM(S): Oryctolagus Cuniculus 
2022-08-10 | PXD035968 |
Sort   by:  
 Page size