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MetabolomicsMyeloid PFKFB3-mediated glycolysis promotes kidney fibrosis
Excessive renal fibrosis is a common pathology in progressive chronic kidney diseases. Inflammatory injury and aberrant repair processes contribute to the development of kidney fibrosis. Myeloid cells, particularly monocytes/macrophages, play a crucial role in kidney fibrosis by releasing their proi...
2024-03-12 | MTBLS8278 | MetaboLights
MetabolomicsPFKFB3-mediated glycolysis boosts fibroblast activation and subsequent kidney fibrosis

Renal fibrosis, a hallmark of chronic kidney diseases, is driven by the activation of renal fibroblasts. Recent studies have highlighted the role of glycolysis in this process. Nevertheless, one critical glycolytic activator, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), remain...

2024-03-12 | MTBLS8281 | MetaboLights
UnknownDesign, Synthesis, and Biological Activities of Novel 1,3,5-Trimethylpyrazole-Containing Malonamide Derivatives.
Not available
S-EPMC6385117 | biostudies-literature
ProteomicsPredicting the efficacy of glucocorticoids in pediatric primary immune thrombocytopenia using plasma proteomics
A four-dimensional data-independent acquisition(4D-DIA) approach was used to analyse protein expression in glucocorticoid-sensitive (GCS) and glucocorticoid-resistant (GCR) children with ITP. 47 differentially expressed proteins (36 up-regulated and 11 down-regulated) were identified in the GCR grou...
ORGANISM(S): Homo sapiens (Human) 
2023-11-28 | PXD046260 | Pride
Immune thrombocytopenia Children 4d-dia Plasma biomarker Glucocorticoids 
UnknownInterleukin-16 enhances anti-tumor immune responses by establishing a Th1 cell-macrophage crosstalk through reprogramming glutamine metabolism in mice.
Not available
S-EPMC11893787 | biostudies-literature
ProteomicsLiquid chromatography mass spectrometry-based nontargeted metabolomics predicts prognosis of hepatocellular carcinoma after curative resection
Assessment and prediction of prognostic risk in patients with hepatocellular carcinoma (HCC) would greatly benefit the optimal treatment selection. Here, we aimed to identify the critical metabolites associated with the outcomes and develop a risk score to assess the prognosis of HCC patients after ...
ORGANISM(S): Homo Sapiens 
2020-06-18 | PXD019864 |
ProteomicsA Metabolite Triplet in Serum Improves the Diagnostic Accuracy of Prediabetes and Diabetes Screening
In this study, applying a novel knowledge-based, multi-stage discovery and validation strategy we scaled down from 108 diabetes–associated metabolites to a diagnostic metabolite triplet (Met-T) and it could improve the diagnostic accuracy of prediabetes and diabetes screening.
ORGANISM(S): Homo Sapiens 
2020-11-30 | PXD022801 |
ProteomicsProteomic analysis of the sperm from Catsperh/tmem262 knock-out mice(WuJianping lab)
We fractionated mouse sperm proteomes using high-pH HPLC, followed by DDA-based spectral library generation. Quantitative DIA analysis was then applied to compare proteomic profiles between Tmem262-/- and WT mice, enabling deep and accurate protein quantification.
ORGANISM(S): Mus Musculus 
2025-12-18 | PXD072173 |
ProteomicsImproving impact of heparan sulfate on the endothelial glycocalyx abnormalities in atherosclerosis as revealed by glycan-protein interactome
Based on glycan-protein interactome, these data expanded the list of known HSBPs and identified them as key proteins in the development of atherosclerosis.
ORGANISM(S): Homo Sapiens 
2023-10-10 | PXD042279 |
ProteomicsDDX5 inhibits hyaline cartilage fibrosis and degradation in osteoarthritis via alternative splicing and G-quadruplex unwinding
Hyaline cartilage fibrosis is one of the important reasons for the poor prognosis of advanced osteoarthritis (OA), and is the main factor leading to joint stiffness and deformity. However, the mechanism of hyaline cartilage fibrosis remains largely unclear. Here we found that DDX5, one of the foundi...
ORGANISM(S): Mus Musculus 
2024-03-13 | PXD050571 |
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