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ProteomicsDiscovery of potential candidate proteins reprogramming spinal cord derived astrocytes into neurons by proteomic analysis
Spinal cord injury (SCI) is a common but devastating trauma of the central nerve system. In this study, we reprogrammed cultured spinal-cord reactive astrocytes into neurons by Neurod1 expression. The mechanism of programmed conversion from astrocytes to neurons has not been clarified yet. Thus, we ...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-09-08 | PXD016097 | Pride
Spinal cord injury Astrocytes Neurons Label-free proteomic analysis Reprogramming 
ProteomicsMultiomics analysis of a DNAH5-mutated PCD organoid model revealed the key role of the TGF-β/BMP and Notch pathways in epithelial differentiation and the immune response in DNAH5-mutated patients
Dynein axonemal heavy chain 5 (DNAH5) is the most mutated gene in primary ciliary dyskinesia (PCD), leading to abnormal cilia ultrastructure and function. Few studies have revealed the genetic characteristics and pathogenetic mechanisms of PCD caused by DNAH5 mutation. Here, we established a child P...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD038024 | Pride
Primary ciliary dyskinesia Immune response Airway organoid Dnah5 Multiomics analysis 
GenomicsHeterochromatin remodeling by CDK12 contributes to learning in Drosophila
We describe the epigenetic profiling of the H3K9me2 and HP1a in Drosophila third instar larvae before and after CDK12 depletion by RNA interference (RNAi). Here we show that CDK12 regulates heterochromatin dynamics in Drosophila chromosomes. Depletion of CDK12 induces the increased HP1a and H3K9me2 ...
ORGANISM(S): Drosophila melanogaster 
2015-11-02 | E-GEOD-63011 | biostudies-arrayexpress
ProteomicsFunctional identification of protocadherin alpha 9 (PCDHA9) as a candidate causative gene for amyotrophic lateral sclerosis
Mice were sacrificed after anesthesia by isoflurane following neck cutting. The spinal cord L3-L5 was taken and frozen in liquid nitrogen immediately and the ventral horn of the bilateral spinal cord (about 400um thick in gray matter area) was collected at low temperature. The samples were digested ...
ORGANISM(S): Mus Musculus 
2023-06-12 | PXD042929 |
ProteomicsProtein from ovarian tissue of Qira black sheep
Proteins were extracted from fresh and intact ovarian tissues, followed by sequencing analysis
ORGANISM(S): Ovis Aries 
2026-03-28 | PXD076327 |
ProteomicsNEAT1 Regulates BMSCs Aging Through Disruption of FGF2 Nuclear Transport
Background: The aging of bone marrow mesenchymal stem cells (BMSCs) impairs bone tissue regeneration, contributing to skeletal disorders. LncRNA NEAT1 is considered as a proliferative inhibitory role during cellular senescence, but the relevant mechanisms remain insufficient. This study aims to eluc...
ORGANISM(S): Homo Sapiens 
2025-01-16 | PXD059860 |
ProteomicsProteogenomic landscape of the Esophageal Squamous Cell Cancer reveals the lipid droplet formation process as a novel therapeutic target
The integrated proteogenomic analysis revealed proteomic characteristics associated with genomic variants and clinical features including arm or focal amplifications, SNV mutations, tumor size, lymph node metastasis, smoking history.
ORGANISM(S): Homo Sapiens 
2025-03-24 | PXD062163 |
ProteomicsProteogenomic landscape of clear cell renal cell carcinoma response to tyrosine kinase inhibitor
We performed proteomic analysis of 115 ccRCC patients samples undergoing sunitinib treatment.
ORGANISM(S): Homo Sapiens 
2023-06-08 | PXD042844 |
ProteomicsProteogenomic Characterization of MiT Family Translocation Renal Cell Carcinoma
Comprehensive proteogenomic analysis of Microphthalmia Transcription Factor (MiT) family translocation renal cell carcinoma (tRCC) tumor and normal adjacent tissues was performed to elucidate the molecular landscape of these tumors.
ORGANISM(S): Homo Sapiens 
2022-07-20 | PXD035377 |
ProteomicsProteomics of the Gastric cancer Response to anti-PD1 therapy
To validate the correlation between Th1/Th2 ratio and immunotherapeutic effectiveness, we collected a group of GC patients treated with anti-PD1 therapy, including 7 responder cases (PR) and 7 non-responder cases (SD/PD). The formalin-fixed paraffin-embedded (FFPE) tumor tissue sections derived from...
ORGANISM(S): Homo Sapiens 
2022-11-17 | PXD038188 |
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