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MetabolomicsTranscriptomic and metabolomic analysis of liver cirrhosis
Liver cirrhosis is one of the leading causes of decreased life expectancy worldwide. However, the molecular mechanisms underlying the development of liver cirrhosis remain unclear. In this study, we performed a comprehensive analysis using transcriptome and metabolome sequencing to explore the genes...
2024-08-07 | MTBLS5665 | MetaboLights
MetabolomicsResearch on the quality markers of antioxidant activity of Kai-Xin-San based on spectrum-effect relationship
Kai-Xin-San (KXS) is one of the classic famous traditional Chinese medicine prescriptions for amnesia, which has been applied for thousands of years. Modern pharmacological research has found that KXS has significant therapeutic efficacy on nervous system diseases, which is related to its antioxidan...
2023-12-21 | MTBLS8806 | MetaboLights
TranscriptomicsA dysregulated Acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity
Acetylation of transcriptional regulators is normally dynamically regulated by nutrient status but is often persistently elevated in nutrient-excessive obesity conditions. We investigated the functional consequences of such aberrantly elevated acetylation of the nuclear receptor FXR as a model. Prot...
ORGANISM(S): Mus musculus 
2014-10-17 | E-GEOD-62414 | biostudies-arrayexpress
ProteomicsLysine methylome features in EZH2 wild-type and mutant lymphoma cell line
We used EZH2i-targeted hematological malignancies as an examples and focused on molecular characterization of EZH2 Y641 mutant hematological cell lines. We used the proteomic strategies and compared the protein expression level and lysine methylation level (including mono-, di-, and trimethylaiton) ...
ORGANISM(S): Homo Sapiens 
2019-12-17 | PXD016779 |
ProteomicsInterorgan communication in the neurogenic heterotopic ossification: focusing on the role of brain-derived extracellular vesicles
Brain-derived extracellular vesicles participate in inter-organ communication after traumatic brain injury by transporting pathogens to initiate secondary injury. Inflammasome related proteins encapsulated in brain-derived extracellular vesicles are capable of crossing the blood-brain barrier to rea...
ORGANISM(S): Rattus Rattus 
2023-11-02 | PXD046626 |
ProteomicsChronic Stress Induced and Tumor Derived SP1+ exosomes Polarizing IL-1β+ Neutrophils to Increase Lung Metastasis of Breast Cancer
We collected tumor-derived exosomes of 4T1 tumor-bearing mice in the control group and the stress group.
ORGANISM(S): Mus Musculus 
2023-12-26 | PXD048125 |
ProteomicsNanoliposuction recycles senescent cell lipids for lubrication
This study aims to systematically profile membrane protein alterations associated with chondrocyte senescence, in order to identify surface markers specifically upregulated in aged cartilage. We established two in vitro models by treating primary chondrocytes with IL-1β or bleomycin, and one in vivo...
ORGANISM(S): Mus Musculus 
PXD064867 |
ProteomicsMultiregional profiling of the brain transmembrane proteome uncovers novel regulators of depression
Our study provides an enabling technology and rich data resources to expand the understanding of transmembrane proteome organization and dynamics in the brain as well as accelerate the discovery of potential therapeutic targets for depression treatment.
ORGANISM(S): Mus Musculus 
2021-07-26 | PXD027559 |
ProteomicsSubcommissural organ (SCO) contributes to brain development via SCO-secreted peptides
To explore the role of SCO and its functional mechanism, we measure the SCO-derived peptide in CSF from C57B/6 mice and SCO-ablated mice.
ORGANISM(S): Mus Musculus 
2025-02-04 | PXD040641 |
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