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ProteomicsProteome-wide analysis and functional identification of lysine β-hydroxybutyrylation in Ustilaginoidea virens
Lysine β-hydroxybutyrylation (Kbhb) is an evolutionarily conserved and widespread post-translational modification (PTM) in active gene transcription and cellular proliferation. However, its function remains unknown in phytopathogenic fungi. Here, we report a comprehensive identification of Kbhb in t...
ORGANISM(S): Ustilaginoidea virens 
2023-10-24 | PXD039304 | Pride
Lysine β-hydroxybutyrylation  post-translational modification  ustilaginoidea virens  virulence 
Proteomicsβ-Hydroxybutyrate Boosts Plant Immunity through Enhanced H3K9bhb Levels and Gene Expression Regulation
Although the functions of protein Kbhb have been widely studied in animal cells, however, the identification and functional characterization of this modification in plants remain unclear. Here, we identified 2,159 Kbhb sites on 1,128 proteins in rice flowers by Kbhb-proteomic analyses, serving as a ...
ORGANISM(S): Oryza sativa (Rice) 
2025-07-05 | PXD051126 | Pride
Lysine β-hydroxybutyrylation 
ProteomicsRedox regulation of cytosolic translation in rice during fungal infection identified by quantitative proteomics
Pathogen attack can increase plant levels of reactive oxygen species (ROS), which then act as signaling molecules activating plant defense. Elucidating these processes is crucial to understanding the redox signaling pathways in plant defense responses. By an iodo TMT–based quantitative proteomic app...
ORGANISM(S): Oryza sativa (Rice) 
2023-06-06 | PXD034430 | Pride
Ros  protein oxidation  translation  infection  immunity  rice 
ProteomicsQuantitative proteomic analysis based on the isobaric tags for relative and absolute quantitation (iTRAQ) labeling in WT and NudCL2 KO-1 HEK-293 cells
Cytokinesis is a key step in the later stage of cell division to partition cellular contents into daughter cells, which undergoes precise regulation in temporal and spatial. However, the underlying mechanisms are still unclear. Here, we show that Hsp90 cochaperone, NudCL2 (NudC-like protein 2), is r...
ORGANISM(S): Homo sapiens (Human) 
2024-03-21 | PXD043570 | Pride
Hek-293 Nudcl2 Itraq 
ProteomicsViperin Mediates Coxsackievirus B3-induced Acute Heart Failure via KCNQ1 Ion Channel
Given that CVB3 is able to impair myocardial contractility, which finally leads to acute heart failure (AHF) and even sudden death, we tried to analyze the related myocardial function of these groups of mice
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD036898 | Pride
Viperin  cvb3  acute heart failure  sgk1 
ProteomicsAK2 promotes the migration and invasion of lung adenocarcinoma by activating TGF-β/Smad pathway in vitro and in vivo
Adenylate kinase 2 (AK2) is a wide-spread and highly conserved protein kinase whose main function is to catalyze the exchange of nucleotide phosphate groups. In this study, we showed that AK2 regulated tumor cell metastasis in lung adenocarcinoma. Positive expression of AK2 is related to lung adenoc...
ORGANISM(S): Homo Sapiens 
2021-09-09 | PXD028231 |
ProteomicsThe aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK
The activity of 5’-adenosine monophosphate-activated protein kinase (AMPK) is inversely correlated with the cellular availability of glucose. When glucose levels are low, the glycolytic enzyme aldolase is not bound to fructose-1,6-bisphosphate (FBP) and, instead, signals to activate lysosomal AMPK. ...
ORGANISM(S): Oryctolagus Cuniculus 
2022-08-10 | PXD035968 |
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