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TranscriptomicsTranscription profiling of human platelets from sickle cell patients reveals changes in arginine metabolic pathways
In sickle cell disease, ischemia-reperfusion injury and intravascular hemolysis produce endothelial dysfunction and vasculopathy characterized by reduced nitric oxide (NO) and arginine bioavailability. Recent functional studies of platelets in patients with sickle cell disease reveal a basally activ...
ORGANISM(S): Homo sapiens 
2008-06-18 | E-GEOD-11524 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of whole blood from sickle-cell disease patients using globin mRNA reduction
Room temperature whole blood mRNA stabilization procedures, such as the PAX gene system, are critical for the application of transcriptional analysis to population-based clinical studies. Global transcriptome analysis of whole blood RNA using microarrays has proven to be challenging due to the high ...
ORGANISM(S): Homo sapiens 
2009-06-20 | E-GEOD-16728 | biostudies-arrayexpress
MetabolomicsMetabolic profilings of rat INS-1 β-cells under changing levels of essential amino acids

Application of mass spectrometry enables the detection of metabolic differences between organisms with different nutritional settings. Divergence in the metabolic fingerprints of rat pancreatic INS-1 β-cells were systematically captured with regard to 10 individual essential amino acid (EAA) avai...

2022-05-24 | MTBLS3963 | MetaboLights
MetabolomicsPrenatal exposure to trace elements impacts mother-infant gut microbiome, metabolome and resistome during the first year of life

Infancy is a critical period for the colonization of the gut microbiome. However, xenobiotic effects on gut microbiome development in early life remain poorly understood. Here, we recruit 146 mother-infant pairs and collect stool samples at 3, 6, and 12 months after delivery for amplicon sequenci...

2025-05-02 | MTBLS11392 | MetaboLights
ProteomicsComprehensive analyses of the macrophages infected with avirulent and virulent Mycobacterium tuberculosis strains uncover distinct immune mechanisms and anti-TB effect of treated exosomes
Protein data of exosomes from Mycobacterium tuberculosis-infected macrophages
ORGANISM(S): Homo Sapiens 
2026-05-18 | PXD078478 |
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