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ProteomicsPull down of Rab10 interactors in Raw264.7 cells
The goal of this project is to identify Rab10 interactors (in presence of GTP/GDP) in Raw264.7 macrophage cells.
ORGANISM(S): Mus musculus (Mouse) 
2022-02-15 | PXD019723 | Pride
Apms Lcms 
MetabolomicsMetabolic profilings of rat INS-1 β-cells under changing levels of essential amino acids

Application of mass spectrometry enables the detection of metabolic differences between organisms with different nutritional settings. Divergence in the metabolic fingerprints of rat pancreatic INS-1 β-cells were systematically captured with regard to 10 individual essential amino acid (EAA) avai...

2022-05-24 | MTBLS3963 | MetaboLights
ProteomicsThe function of sirtuin family in NER
The role of sirtuin family in regulating DNA DSB repair has been extensively investigated, and here, we explore the molecular mechanisms of Sirtuin family in nucleotide excision repair.
ORGANISM(S): Homo Sapiens 
PXD020721 |
ProteomicsLiP-small molecule mapping of Farrerol
Limited proteolysis combined with mass spectrometry of farrerol treated. Briefly, cell lysates containing approximately 500 μg of total protein sample were incubated with farrerol or vehicle (DMSO) for 10 min at 25 °C. Proteinase K (5 μg, Sigma–Aldrich) was added simultaneously to each sample for t...
ORGANISM(S): Homo Sapiens 
2022-08-25 | PXD036308 |
ProteomicsHistone PTMs dataset for Hyposuccinylation Derived from Abnormal Metabolism Promotes the Cell Migration of Esophageal Squamous Cell Cancer
We identify abnormal protein and post-translational modification (PTM) pathways, including many downregulated lysine succinylation sites in cancer cells. Focusing on hyposuccinylation, we reveal that this altered PTM was enriched on enzymes of metabolic pathways and the reduced succinyl-CoA may lead...
ORGANISM(S): Homo Sapiens 
PXD021700 |
ProteomicsProteome-wide Hyposuccinylation of Esophageal Squamous Cell Cancer to Promotion of Tumor Metabolism and Migration
We identify abnormal protein and post-translational modification (PTM) pathways, including significantly downregulated lysine succinylation sites in cancer cells. Focusing on hyposuccinylation, we reveal that this altered PTM was enriched on enzymes of metabolic pathways inextricably linked with can...
ORGANISM(S): Homo Sapiens 
PXD021567 |
ProteomicsMouse Testis IP-MS Analysis of TEX44 Interacting Proteins
Through whole-exome sequencing of 800 patients with asthenozoospermia, we identified biallelic TEX44 variants in six individuals, all of whom exhibited defective mitochondrial sheath assembly and impaired sperm motility. Using Tex44 knockout mice, we demonstrated that TEX44 interacts with carnitine ...
ORGANISM(S): Mus Musculus 
2025-02-20 | PXD060989 |
ProteomicsTargeting the Golgi apparatus enhances PD-L1 blockade and synergizes with oxaliplatin to improve immunotherapy efficacy
Proteomic profiling of differentially expressed proteins of 4T1 cells induced by liposome.
ORGANISM(S): Mus Musculus 
2026-02-03 | PXD073979 |
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