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UnknownDifferential Requirements for Tcf1 Long Isoforms in CD8+ and CD4+ T Cell Responses to Acute Viral Infection.
Not available
S-EPMC5531591 | biostudies-literature
UnknownCutting Edge: Tcf1 Instructs T Follicular Helper Cell Differentiation by Repressing Blimp1 in Response to Acute Viral Infection.
Not available
S-EPMC6684471 | biostudies-literature
UnknownCutting Edge: β-Catenin-Interacting Tcf1 Isoforms Are Essential for Thymocyte Survival but Dispensable for Thymic Maturation Transitions.
Not available
S-EPMC5423537 | biostudies-literature
TranscriptomicsExpression data from WT and TCF-1-deficient memory CD8 T cells
TCF-1 is an HMG family transcription factor which is known to be activated by the canonical Wnt signaling pathway and modulated by other signals such as those derived from T cell receptor. We found that during CD8 T cell responses, TCF-1 deficiency impaired long-term maintenance of antigen-specific ...
ORGANISM(S): Mus musculus 
2010-10-04 | E-GEOD-20754 | biostudies-arrayexpress
TranscriptomicsExpression data from WT and GABPalpha-deficient Flt3(-) LSK cells
GABPalpha is an Ets family transcription factor and involved in regulation of both basic cellular functions such as cell cycle progression and tissue-specific biological processes. We found that GABPalpha is critically required for survival and differentiation of hematopoietic stem cells. We used mi...
ORGANISM(S): Mus musculus 
2011-07-27 | E-GEOD-23341 | biostudies-arrayexpress
UnknownEzh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf.
Not available
S-EPMC6303346 | biostudies-literature
TranscriptomicsExpression data from WT DN3, TCF-1-deficient DN3 thymocytes, and T cell lymphomas in TCF-1-deficient animals.
TCF-1 is an HMG family transcription factor which is known to be critical for T cell development. We discovered that it has a unique role in suppressing malignant transformation of developing thymocytes at early stages. We identified ID2 and LEF-1 as key TCF-1 target genens in tumor suppression. We ...
ORGANISM(S): Mus musculus 
2012-10-25 | E-GEOD-33292 | biostudies-arrayexpress
UnknownTcf1 and Lef1 are required for the immunosuppressive function of regulatory T cells.
Not available
S-EPMC6446865 | biostudies-literature
GenomicsGenome-wide mapping of the transcription factor GABP-alpha binding in human CD34+CD133+ hematopoietic progenitor cells.
We used ChIP-Seq to map GABP-alpha binding sites in human hematopoietic progenitor cells (HPCs). Coupled with functional assays using GABP-alpha deficient mouse model and bioinformatics analysis, we systematically determined a transcriptional module controlled by GABP in HPCs. Examination of the rol...
ORGANISM(S): Homo sapiens 
2010-12-10 | E-GEOD-24933 | biostudies-arrayexpress
UnknownTle corepressors are differentially partitioned to instruct CD8+ T cell lineage choice and identity.
Not available
S-EPMC6080905 | biostudies-literature
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