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Nrf2 (NF-E2-related-factor-2) contributes to the maintenance of glucose homeostasis in vivo. Nrf2 suppresses blood glucose levels by protecting pancreatic β-cells from oxidative stress and improving peripheral tissue glucose utilization. To elucidate the molecular mechanisms by which Nrf2 contribut...
ORGANISM(S): Mus musculus 
Arabidopsis plants (Col-0) were hydroponically grown for 10 days at 22°C under 30~40 μE·m−2·s−1 and continuous light conditions. Treatment with 100 mM H2O2 or sterile distilled water as mock control by spraying for shoot treatments, or dipping for root treatments. Relationship between treated and ha...
ORGANISM(S): Arabidopsis thaliana 
The purpose of the present study was to investigate the association of glutathione S-transferase P1 (GSTP1) expression with resistance to neoadjuvant paclitaxel followed by 5-fluorouracil/epirubicin/cyclophosphamide (P-FEC) in human breast cancers. The relationship of GSTP1 expression and GSTP1 prom...
ORGANISM(S): Homo sapiens 
Prostate cancer cell lines were cultured with serum-free media, for 48 h. The cultured media were collected and lyophilized. The lyophilized media were dissolved in ammonium bicarbonate containing 4 M urea, and proteins were de-salted by acetone-precipitation and subjected to proteome analysis.
ORGANISM(S): Homo Sapiens (human) 
We successfully constructed a customized spectral library containing information on 1,394 proteins for DIA-MS; the library can be used for comprehensive identification and quantification of proteins expressed in the mouse bones.
ORGANISM(S): Mus Musculus (mouse) 
This project is “Medical proteome analysis of osteoporosis- and bone mass-related proteins using the Kibo Japanese Experiment Module of International Space Station (ISS)”. Utilizing proteomic technologies, this research aims to identify proteins involved in space flight-induced osteopenia as well as...
ORGANISM(S): Mus Musculus (mouse) 
The molecular mechanisms associated with spaceflight-induced biological adaptations that may affect many healthy tissue functions remain poorly understood. In this study, we analyzed temporal changes in the serum proteome of six astronauts during prolonged spaceflight missions using quantitative com...
ORGANISM(S): Homo Sapiens (human) 
In this project we aimed to investigate the effect of Goreisan (GRS, traditional herbal medicine) on HFpEF model heart failure mouse. HFpEF was induced by administration of high-fat diet (HFD)and N-nitro-L-arginine methyl ester (L-NAME), with or without GRS. Mouse heart proteome was analyzed with LC...
ORGANISM(S): Mus Musculus (mouse) 
The COVID-19 pandemic is an unprecedented threat to humanity that has provoked global health concerns. Since the etiopathogenesis of this illness is not fully characterized, the prognostic factors enabling treatment decisions have not been well documented. Accurately predicting the progression of th...
ORGANISM(S): Homo Sapiens (human) 
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