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MetabolomicsSCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia
Acute myeloid leukemia (AML) cells rely on phospho-signaling pathways to gain unlimited proliferation potential. Here, we used domain-focused CRISPR screening to identify the nuclear phosphatase SCP4 as a dependency in AML, yet this enzyme is dispensable in normal hematopoietic progenitor cells. Usi...
2025-05-29 | MTBLS3707 | MetaboLights
UnknownModulation of the Gut Microbiota by Shen-Yan-Fang-Shuai Formula Improves Obesity Induced by High-Fat Diets.
Not available
S-EPMC7779482 | biostudies-literature
Proteomicsc-di-GMP affect the protein acetylation through CobB dependent deacetylation
To determine whether c-di-GMP could affect CobB-dependent deacetylation in a global setting, we applied Stable Isotope Labeling with Amino acids in Cell culture (SILAC) coupled with MS to quantitatively compare the levels of protein acetylation in WT, ΔcobB and ΔdgcZ cells.
ORGANISM(S): Escherichia coli 
2019-06-17 | PXD013292 | Pride
C-di-gmp cobb 
MetabolomicsComprehensive evaluation of untargeted metabolomics data processing software in feature detection, quantification and discriminating marker selection (AB SCIEX TripleTOF 6600 assay)

Data analysis represents a key challenge for untargeted metabolomics studies and it commonly requires extensive processing of more than thousands of metabolite peaks included in raw high-resolution MS data. Although a number of software packages have been developed to facilitate untargeted data p...

2019-11-19 | MTBLS736 | MetaboLights
UnknownInvolvement of specific striatal subregion contributes to executive deficits in Alzheimer disease.
Not available
S-EPMC10095253 | biostudies-literature
ProteomicsProtein Deacetylase CobB Interplays with c-di-GMP
As a ubiquitous bacterial secondary messenger, c-di-GMP plays key regulatory roles in processes like bacterial motility and transcription regulation. We found that c-di-GMP had impact on lysine acetylation level. To further investigate the regulation role, we performed a quantitative analysis of E. ...
ORGANISM(S): Escherichia coli 
2019-06-17 | PXD010558 | Pride
C-di-gmp Ydeh Acetylation 
TranscriptomicsTranscription profiling of human stage non-small cell lung cancer samples, metaanalysis for a predictive signature
We applied a meta-analysis of datasets from seven different microarray studies on lung cancer for differentially expressed genes related to survival time (under 2 y and over 5 y). Systematic bias adjustment in the datasets was performed by distance-weighted discrimination (DWD). We identified a gene...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6253 | biostudies-arrayexpress
UnknownComparison of Functional Components and Antioxidant Activity of Lycium barbarum L. Fruits from Different Regions in China.
Not available
S-EPMC6632000 | biostudies-literature
UnknownL-theanine prevents progression of nonalcoholic hepatic steatosis by regulating hepatocyte lipid metabolic pathways via the CaMKKβ-AMPK signaling pathway.
Not available
S-EPMC9013079 | biostudies-literature
UnknownUtilizing SSR-based core collection development to improve conservation and utilization of Corylus L. genetic resources.
Not available
S-EPMC11521296 | biostudies-literature
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