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MetabolomicsTFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis
The mechanisms underlying cancer metastasis remain poorly understood. Here, we report that TFAM deficiency rapidly and stably induced spontaneous lung metastasis in mice with liver cancer. Interestingly, unexpected polymerization of nuclear actin was observed in TFAM-knockdown HCC cells when cytoske...
2022-06-23 | MTBLS4307 | MetaboLights
TranscriptomicsIntegration of developmental and nutritional cues determines timing of female flower opening in cucumber
The timing of flower opening is essential for pollination and thus seed production. Despite flower opening has been a long lasting topic for plant biologists, the underling molecular mechansim remains elusive. Here we used a unique cucumber line ‘6457’ that spontaneously produces super ovary wit...
ORGANISM(S): Cucumis sativus 
2016-07-25 | E-GEOD-76358 | biostudies-arrayexpress
ProteomicsTengdan Capsule Prevents Hypertensive Kidney Damage in SHR by Inhibiting Periostin-mediated Renal Fibrosis
In order to reveal the potential molecular mechanism of TDC in renal protection of rats with essential hypertension, TMT-based quantitative proteomics analysis method was used to conduct quantitative analysis of proteins extracted from kidney of SHR of model and TDC treatment groups after 4 weeks of...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-09-10 | PXD024102 | Pride
Teng dan capsule  hypertension-induced kidney damage  periostin  tgfβ/smad signaling pathway  inflammatory response  human kidney hek293 cells 
ProteomicsCombine in silico target fishing, Comparative proteomics analysis and in vitro assays to identify antibacterial effects of a TCM (the leaves of Strobilanthes cusia Kuntze) against the Penicillin resistant Streptococcus pneumoniae
The anti-bacterial mechanism of the leaves of Strobilanthes cusia Kuntze against the Penicillin-resistant Streptococcus pneumoniae were analyzed by the comparative proteomics
ORGANISM(S): Streptococcus Pneumoniae 23f 
2022-12-18 | PXD038886 |
TranscriptomicsSmall RNAs as important regulators for the hybrid vigour of super-hybrid rice
Heterosis is an important biological phenomenon; however, the role of small RNA (sRNA) in heterosis of hybrid rice remains poorly described. Here, we performed sRNA profiling of F1 super-hybrid rice LYP9 and its parents using high-throughput sequencing technology, and identified 355 distinct mature ...
ORGANISM(S): Oryza sativa 
2014-08-17 | E-GEOD-51468 | biostudies-arrayexpress
MetabolomicsMechanisms of hepatic steatosis in chickens: integrated analysis of the host genome, molecular phenomes and gut microbiome

Hepatic steatosis is the initial manifestation of abnormal liver functions and often leads to liver diseases such as non-alcoholic fatty liver disease in humans and fatty liver syndrome in animals. In this study, we conducted a comprehensive analysis of a large chicken population consisting of 70...

2023-07-24 | MTBLS7808 | MetaboLights
ProteomicsRBIS regulates ribosome biogenesis to affect progression in lung adenocarcinoma
Transient overexpress RBIS and control plasmid in H293T cells and collect cells after 48 hours, then performed IP assays using anti-Flag beads subjected samples to LC-MSMS to screen proteins interacting with RBIS.
ORGANISM(S): Homo Sapiens 
2024-10-23 | PXD057090 |
UnknownLong-term open-label vebicorvir for chronic HBV infection: Safety and off-treatment responses.
Not available
S-EPMC10951643 | biostudies-literature
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