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UnknownCircular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice.
Not available
S-EPMC6949063 | biostudies-literature
ProteomicsMDGA2 constrains the BDNF/TrkB signaling
MDGA2 is an excitatory synaptic suppressor and its mutations have been associated with autism spectrum disorder (ASD). However, the detailed physiological function of MDGA2 and the mechanism underlying MDGA2 deficiency-caused ASD has yet to be elucidated. Herein, we not only confirm that Mdga2+/- mi...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-06 | PXD050810 | Pride
Asd Mdga2 Bdnf Trkb 
UnknownSocial support and medication adherence among adult myasthenia gravis patients in China: the mediating role of mental health and self-efficacy.
Not available
S-EPMC10993533 | biostudies-literature
MetabolomicsTargeting the SREBP-dependent lipidomic reprogramming by virus infection for broad-spectrum therapeutic intervention
Viruses are obligate intracellular parasites that exploit the host metabolic machineries to meet their extraordinary biosynthetic demands. Integrative transcriptomic and lipidomic profiling confirmed that Middle East respiratory syndrome coronavirus (MERS-CoV) infection reprograms the host lipid met...
2018-11-26 | MTBLS762 | MetaboLights
ProteomicsMulti-omics integrative analysis reveals that burdock seed aglycone alleviates renal fibrosis by restoring mitochondrial oxidative phosphorylation function
Renal fibrosis (RF) is a common pathological process in the progression of chronic kidney disease (CKD) to end-stage renal failure and is also a key target for the prevention and treatment of kidney diseases. It is closely associated with mitochondrial dysfunction, particularly impaired oxidative ph...
ORGANISM(S): Rattus Norvegicus 
2026-02-06 | PXD074134 |
ProteomicsBiomarker Prediction for Lung Cancer Chemoradiotherapy Efficacy Based on Proteomics
The response of lung cancer to chemoradiotherapy (CRT) is orchestrated by the dynamic interplay between immune microenvironment remodeling and metabolic reprogramming. However, robust biomarkers for predicting patient prognosis remain elusive. In this study, we performed proteomics profiling of 22 p...
ORGANISM(S): Homo Sapiens 
2026-03-19 | PXD075840 |
UnknownGenome-Wide Analysis of the Lateral Organ Boundaries Domain (LBD) Gene Family in Solanum tuberosum.
Not available
S-EPMC6861928 | biostudies-literature
ProteomicsRNA-Binding Motif protein 6 is a candidate serum biomarker for pancreatic cancer
Early diagnosis is crucial to improve outcomes for pancreatic cancer (PC) patients, however the lack of specific and validated biomarkers for the disease remains challenging. In this study, we analyzed the serum proteome of 12 PC patients and 76 healthy controls (HC), using magnetic bead-based weak ...
ORGANISM(S): Homo Sapiens 
2019-04-25 | PXD013626 |
ProteomicsQuantitative proteomic analysis reveals the expression of various proteins in mice during the tumor treatment
Based on the gene ontology (GO) results, we found that proteins associated with responses or processes related to stimulus, immune system, signalling, cell killing, and antioxidant activity were more up-regulated after MiBaMc treatment. In contrast, proteins that related to cell integrity and cell g...
ORGANISM(S): Mus Musculus 
2022-09-28 | PXD037069 |
ProteomicsQuartet Protein Reference Materials for Multi-platform Assessment of Label-free Proteomics
We developed the Quartet as a bulk of proteome reference materials with built-in truth, and distributed the same aliquots to 15 laboratories in six cities of China with nine conventional LC-MS/MS platforms. Relative protein abundances from over 12,000 proteins on 816 MS files were obtained and compa...
ORGANISM(S): Homo Sapiens 
2023-06-24 | PXD043262 |
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