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TranscriptomicsThe role of the Ras- and cAMP-signaling pathways in stress response and sterol biosynthesis in Cryptococcus neoformans
The cAMP-pathway plays a central role in regulation of growth, differentiation, and virulence of human pathogenic fungi, including Cryptococcus neoformans. Three major upstream signaling regulators of the adenylyl cyclase (Cac1), Ras, Aca1 (Adenylyl cyclase-associated protein 1) and G-alpha subunit ...
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2010-05-22 | E-GEOD-17338 | biostudies-arrayexpress
UnknownSafety and efficacy of glibenclamide combined with rtPA in acute cerebral ischemia with occlusion/stenosis of anterior circulation (SE-GRACE): a randomized, double-blind, placebo-controlled trial.
Not available
S-EPMC10641480 | biostudies-literature
UnknownSafety and efficacy of glibenclamide combined with rtPA in acute cerebral ischemia with occlusion/stenosis of anterior circulation (SE-GRACE): study protocol for a randomized controlled trial.
Not available
S-EPMC7291425 | biostudies-literature
TranscriptomicsHT-SELEX of recombinant C2H2 zinc finger domains of Sall4
To define the sequence preference of SALL4 C2H2 zinc finger domains, we performed SELEX coupled with high-throughput sequencing (HT-SELEX) using the purified SALL4 ZFC1, ZFC2 and ZFC4 domains combined with no protein control experiment.
ORGANISM(S): artificial sequences 
2021-01-05 | E-MTAB-9236 | biostudies-arrayexpress
TranscriptomicsThe bZIP transcription factor Atf1 governs the oxidative stress response and sexual differentiation of Cryptococcus neoformans downstream of the HOG pathway
The high osmolarity glycerol response (HOG) pathway plays a pivotal role in the stress response, virulence regulation, and differentiation of fungi, including Cryptococcus neoformans that causes fatal meningoencephalitis. Core signaling components of in the HOG pathway, including the Tco-Ypd1-Ssk1 p...
ORGANISM(S): Cryptococcus neoformans var. grubii 
2015-01-13 | E-GEOD-64871 | biostudies-arrayexpress
ProteomicsCFAP418 participates in membrane-associated cellular processes through binding lipids during ciliogenesis
iliopathies and retinal degenerative diseases are heterogeneous groups of genetic diseases. CFAP418 is a causative gene of both diseases, and its sequence is evolutionarily conserved. Here, we employ affinity purification coupled with mass spectrometry and quantitative lipidomic, proteomic, and phos...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-05-05 | MSV000089424 | MassIVE
ProteomicsLabel-free semi-quantitative proteome profiling of retinas at P5 of Wild type and Cfap418-/- mice
Label-free semi-quantitative proteome profiling of retinas at P5 of Wild type and Cfap418-/- mice
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-04-29 | MSV000089334 | MassIVE
UnknownA Machine Learning Model for Predicting In-Hospital Mortality in Chinese Patients With ST-Segment Elevation Myocardial Infarction: Findings From the China Myocardial Infarction Registry.
Not available
S-EPMC11322712 | biostudies-literature
ProteomicsAggregated proteome of MDK model mice
MDK is a heparin-binding growth factor and found to be the Aβ associated protein. Through aggregated proteome, we aim to identify DE proteins more associated with plaques by MDK knockout.
ORGANISM(S): Mus musculus (Mouse) 
2025-07-16 | PXD045746 | Pride
Mdk  aggregated proteome  mice 
ProteomicsWhole proteome of MDK model mice
MDK is a heparin-binding growth factor and found to be the Aβ associated protein. AD mouse model of MDK knockout was established to provide the animal tool to investigate the effect of MDK on AD. Through proteome, we aim to study the Aβ change and identify the DE proteins by MDK knockout to know how...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-16 | PXD046539 | Pride
Whole proteome Mdk Mice 
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