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MetabolomicsFSCN1 as a new druggable target in adrenocortical carcinoma

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a high risk of relapse and metastatisation. The actin-bundling protein fascin (FSCN1) is overexpressed in aggressive ACC and represents a reliable prognostic indicator. FSCN1 has been shown to synergize with the Rho/Rac GEF VAV2 i...

2023-03-20 | MTBLS6402 | MetaboLights
TranscriptomicsPhenotypic and transcriptional analysis of the osmotic regulator OmpR in Yersinia pestis
Background The osmotic regulator OmpR in Escherichia coli regulates differentially the expression of major porin proteins OmpF and OmpC. In Yersinia enterocolitica and Y. pseudotuberculosis, OmpR is required for both virulence and survival within macrophages. However, the phenotypic and regulatory r...
ORGANISM(S): Yersinia pestis 
2011-10-23 | E-GEOD-26601 | biostudies-arrayexpress
TranscriptomicsExpression data of HGF/cMET pathway in prostate cancer DU145 cell line
DU145 prostate cancer cells were treated with 25 ng/ml hepatocyte growth factor (HGF) or vehicle for 2, 8, or 24 hours. HGF stimulates the cMET protein, a tyrosine kinase transmembrane protein. The aim of this study is to determine the role of the HGF/cMET pathway in immature cells of established pr...
ORGANISM(S): Homo sapiens 
2011-12-16 | E-GEOD-16659 | biostudies-arrayexpress
ProteomicsEffects of FSCN1 inactivation on protein expression in human adrenocortical cancer cells
Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a high risk of relapse and metastatisation. The actin-bundling protein fascin (FSCN1) is overexpressed in aggressive ACC and represents a reliable prognostic indicator. FSCN1 has been shown to synergize with the Rho/Rac GEF VAV2 in e...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-11-18 | MSV000090738 | MassIVE
UnknownProtein Nanofibril Assemblies Templated by Graphene Oxide Nanosheets Accelerate Early Cell Adhesion and Induce Osteogenic Differentiation of Human Mesenchymal Stem Cells.
Not available
S-EPMC6310480 | biostudies-literature
MetabolomicsRegulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage

Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regul...

2023-10-10 | MTBLS8391 | MetaboLights
UnknownS-adenosylmethionine upregulates the angiotensin receptor-binding protein ATRAP via the methylation of HuR in NAFLD.
Not available
S-EPMC7985363 | biostudies-literature
UnknownCytological Observation and Transcriptome Comparative Analysis of Self-Pollination and Cross-Pollination in Dendrobium Officinale.
Not available
S-EPMC8002659 | biostudies-literature
Transcriptomicsdelta-arcS versus wild-type
The availability of oxygen is a major environmental factor for many microbes, in particular for bacteria, such as Shewanella species, which thrive in redox-stratified environments. One of the best studied systems involved in mediating the response to changes in environmental oxygen levels is the Arc...
ORGANISM(S): Shewanella oneidensis MR-1 
2010-06-05 | E-GEOD-21044 | biostudies-arrayexpress
UnknownConnexin 43 confers resistance to hydrogen peroxide-mediated apoptosis.
Not available
S-EPMC2001300 | biostudies-literature
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