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ProteomicsS-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons
A causal relationship between mitochondrial metabolic dysfunction and neurodegeneration has been strongly implicated in synucleinopathies, including Parkinson’s disease (PD) and Lewy body dementia (LBD), but the underlying molecular basis is not fully understood. Here, using human induced pluripoten...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD036797 | Pride
S-nitrosylation Alpha-synuclein Tca cycle Mitochondrial dysfunction 
UnknownMyocardial brain-derived neurotrophic factor regulates cardiac bioenergetics through the transcription factor Yin Yang 1.
Not available
S-EPMC10226756 | biostudies-literature
ProteomicsS-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons
Here, we used a method, SNO trapping by triaryl phosphine (SNOTRAP), combined with mass spectrometry, to identify SNO-proteins present in post-mortem brain samples. Following analysis of SNO-proteins in samples of 11 human brains from patients LBD and controls, we detected 943 SNO-proteins and 1,552...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD036703 | Pride
Lbd Human brain Snotrap 
UnknownComparison of Cyclic and Linear Poly(lactide)s Using Small-Angle Neutron Scattering.
Not available
S-EPMC9798859 | biostudies-literature
UnknownS-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons.
Not available
S-EPMC10530441 | biostudies-literature
UnknownMedicaid Expansion And Outpatient Cardiovascular Care Use Among Low-Income Nonelderly Adults, 2012-15.
Not available
S-EPMC10923246 | biostudies-literature
UnknownMolecular structure, NBO analysis of the hydrogen-bonded interactions, spectroscopic (FT-IR, FT-Raman), drug likeness and molecular docking of the novel anti COVID-2 molecule (2E)-N-methyl-2-[(4-oxo-4H-chromen-3-yl)methylidene]-hydrazinecarbothioamide (Dimer) - quantum chemical approach.
Not available
S-EPMC7834302 | biostudies-literature
Transcriptomicstranscriptome analysis of differentially expressed genes in the harlequin (hlq) mutant
Plant growth and development is continuous and modular, a combination that allows morphogenesis by controlled cell division and elongation and serves to facilitate plantsM-bM-^@M-^Y adaptations to changing environments. Plasticity is achieved through integration of external and internal signals to ...
ORGANISM(S): Arabidopsis thaliana 
2014-06-03 | E-GEOD-45806 | biostudies-arrayexpress
UnknownVariation in blood microbial lipopolysaccharide (LPS) contributes to immune reconstitution in response to suppressive antiretroviral therapy in HIV.
Not available
S-EPMC9065923 | biostudies-literature
UnknownMethotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia.
Not available
S-EPMC3948096 | biostudies-literature
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