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GenomicsDNA methylation and the adverse metabolic outcomes of adiposity
Overweight and obesity affect ~1.5 billion people worldwide, and are major risk factors for type-2 diabetes (T2D), cardiovascular disease and related metabolic and inflammatory disturbances.1,2 Although the mechanisms linking adiposity to its clinical sequelae are poorly understood, recent studies s...
EGAS00001001922 | EGA
GenomicsBMI EWAS summary stats
Summary statistics for a multi-cohort epigenome-wide association study. This includes summary statistics (effect-size, standard error, p-value) for 470,000 methylation markers.
EGAD00010001029 | EGA
UnknownPrognostic value of HER2 status on circulating tumor cells in advanced-stage breast cancer patients with HER2-negative tumors.
Not available
S-EPMC7299127 | biostudies-literature
TranscriptomicsHuman Aging-associated DNA Hypermethylation Occurs Preferentially at Bivalent Chromatin Domains
There is a growing realization that some aging-associated phenotypes/diseases have an epigenetic basis. Here we report the first genome-scale study of epigenomic dynamics during normal human aging. We identify aging-associated differentially methylated regions (aDMRs) in whole blood in a discovery c...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-20236 | biostudies-arrayexpress
TranscriptomicsHuman Aging-associated DNA Hypermethylation Occurs Preferentially at Bivalent Chromatin Domains
There is a growing realization that some aging-associated phenotypes/diseases have an epigenetic basis. Here we report the first genome-scale study of epigenomic dynamics during normal human aging. We identify aging-associated differentially methylated regions (aDMRs) in whole blood in a discovery c...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-20242 | biostudies-arrayexpress
UnknownHuman aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains.
Not available
S-EPMC2847746 | biostudies-literature
ModelsT-LGL Survival Network 2008
T cell large granular lymphocyte (T-LGL) leukemia features a clonal expansion of antigen-primed, competent, cytotoxic T lymphocytes (CTL). To systematically understand signaling components that determine the survival of CTL in T-LGL leukemia, we constructed a T-LGL survival signaling network by inte...
2176 | Cell Collective
TranscriptomicsExercise-associated changes of leukocyte gene expression in Stratin-associated myopathy - A case study
Biological Relevance and Intent of the Experiment Statin-associated muscle symptoms (SAMS) are among the most common adverse effects limiting the use of statin therapy, yet their underlying biological mechanisms remain poorly defined. While metabolic and structural causes have been proposed, increas...
ORGANISM(S): Homo sapiens 
2025-11-13 | E-MTAB-15840 | biostudies-arrayexpress
UnknownGene expression changes with age in skin, adipose tissue, blood and brain.
Not available
S-EPMC4054017 | biostudies-literature
TranscriptomicsThe maize leaf transcriptome
We have generated over 80 million 32 nt reads generated from RNA samples isolated from the tip and base of a developing Mo17 leaf. A comparision of these data with the maize AGP resulted in the confirmation of approximately 88% of the maize filtered gene set Keywords: Transcriptome analysis Examin...
ORGANISM(S): Zea mays 
2009-08-15 | E-GEOD-16916 | biostudies-arrayexpress
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