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UnknownObesity promotes gastric cancer metastasis via diacylglycerol acyltransferase 2-dependent lipid droplets accumulation and redox homeostasis.
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S-EPMC7276427 | biostudies-literature
ProteomicsProteomic study of Toxoplasma gondii infection in cibeaver
Proteomics in South China Agricultural University essentially refers to the study of protein characteristics at a large-scale level, including protein expression level, post-translational modification, protein-protein interaction and so on, so as to obtain an overall and comprehensive understanding ...
ORGANISM(S): Paguma Larvata 
2022-11-09 | PXD038083 |
ProteomicsProteome, lysine acetylome and succinylome identify post-translational modification of STAT1 as a novel drug target in silicosis
Inhalation of crystalline silica dust induces incurable lung damage, silicosis and pulmonary fibrosis. However, the mechanisms of the lung injury remain poorly understood, with limited therapeutic options aside from lung transplantation. Post-translational modifications can regulate the function of...
ORGANISM(S): Mus Musculus 
2024-02-04 | PXD049146 |
MetabolomicsVGLL4 modulates Paneth cells and sustains intestinal homeostasis.
Paneth cells are defensive cells in the intestinal tract, which secrete niche factors and antimicrobial peptides (AMPs) to maintain the small intestinal stem cell niche and immune homeostasis. Here, we show that Vestigial-like family member 4 (VGLL4) plays a pivotal role in maintaining small intesti...
2026-03-12 | MTBLS10456 | MetaboLights
ProteomicscTAGE5/MEA6 regulates LBR transport to maintain nuclear envelope integrity and safeguard against aging
IP-MS of fused MEA6-GFP and the control sample were performed. For MS analyses, peptides were resuspended in 0.1% FA and analyzed by LTQ Orbitrap Elite mass spectrometer (ThermoFisher Scientific) coupled online to an Easy-nLC 1000 (Thermo Fisher Scientific) in the data-dependent mode.
ORGANISM(S): Homo Sapiens 
2025-04-24 | PXD063263 |
ProteomicsNovel phenotypes of immune-mediated necrotizing myopathy identified independent of myositis-specific antibody specificity that improve prognostic stratification
Immune-mediated necrotizing myopathy (IMNM) is a severe autoimmune myopathy with high clinical heterogeneity. Current classification relies on myositis-specific antibodies (MSA: anti-HMGCR, anti-SRP) but fails to explain differences in manifestations, interstitial lung disease (ILD) incidence, and s...
ORGANISM(S): Homo Sapiens 
2026-05-06 | PXD078154 |
ProteomicsSpatial phosphoproteomics reveals phosphorylation features in liver cirrhosis
Liver cirrhosis (LC) is the end stage of chronic liver disease, characterized by pseudolobule formation and extensive fibrosis, with unclear regional dynamics of protein phosphorylation. This study used spatial phosphoproteomics combined with bioinformatics to analyze phosphorylation patterns in LC ...
ORGANISM(S): Homo Sapiens 
2025-11-21 | PXD071108 |
ProteomicsProteome and phosphoproteome landscape of silicosis occurrence in mice model
To map the multi-omics atlas of silicosis progression, we collected four replicates of whole lung lobes from mice at different stages (W2, W4, W6, W10) after silica-treated as well as W6 after PBS-treated (as control). Then we performed (phospho) proteome analysis as well as bioinformatic analysis.
ORGANISM(S): Mus Musculus 
2021-08-04 | PXD027693 |
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