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ProteomicsPyruvate facilitates FACT-mediated γH2AX loading to chromatin and promotes the radiation resistance of glioblastoma
DNA repair confers the resistance of tumor cells to DNA-damaging anticancer therapies, while how reprogrammed metabolism in tumor cells contributes to such process remains poorly understood. Pyruvate kinase M2 isoform (PKM2) catalyzes the conversion of phosphoenolpyruvate to pyruvate and regulates t...
ORGANISM(S): Homo Sapiens Escherichia Coli 
2021-11-18 | PXD029790 |
ProteomicsPFKM promotes the survival of GBM cells under glucose deprivation
PFKM is the second rate-limiting step of glycolysis, catalyzing the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate. Here we show, using an orthotopic xenograft glioma mouse model, that PFKM is deubiquitinated and translocated into nucleus upon glucose deficiency, thereby activa...
ORGANISM(S): Homo Sapiens 
2026-02-15 | PXD074827 |
TranscriptomicsExpression data from transgenic rice with OsEATB
Rice ethylene-response AP2/ERF factor OsEATB restricts internode elongation by down-regulating gibberellin biosynthetic gene Leaf tissues of 4-leaf-old transgenic and nontransgenic seedlings (10 plants each), respectively, were selected.
ORGANISM(S): Oryza sativa 
2011-07-01 | E-GEOD-28229 | biostudies-arrayexpress
TranscriptomicsExpression data from FCA-csRRM2 transgenic B. napus
Over-expression of a conserved RRM domain (csRRM2) improves Brassica napus yield components by regulating cell size Leaf tissues of one-month-stage transgenic and nontransgenic seedlings (3 plants each),respectively,were selected.
ORGANISM(S): Brassica napus 
2011-11-01 | E-GEOD-32167 | biostudies-arrayexpress
TranscriptomicsNext Generation Sequencing Facilitates Quantitative Analysis of Wild Type and opaque2 mutant Transcriptomes
Analysis of gene expression level. The hypothesis tested in the present study was that opaque2 mutant influence the expression of storage proteins. Results provide important information of the gene expression level regulation of storage proteins and other biological processes. Endosperm mRNA profil...
ORGANISM(S): Zea mays 
2014-10-15 | E-GEOD-61830 | biostudies-arrayexpress
TranscriptomicsInvestigating the role of OsPDCD5 in rice programmed cell death by inducible expression
Overexpression of programmed cell death 5 gene (PDCD5) in tumor cells enhances apoptosis triggered by growth factor or serum deprivation, and overexpression of its homolog, OsPDCD5, induces the early death of transgenic plants. In this work, a system of inducible OsPDCD5 expression using a heat shoc...
ORGANISM(S): Oryza sativa 
2011-06-30 | E-GEOD-18900 | biostudies-arrayexpress
MetabolomicsMetabolomic analysis of alfalfa (Medicago sativa L.) root-symbiotic rhizobia responses under alkali stress
Alkaline salts (e.g., NaHCO3 and Na2CO3) causes more severe morphological and physiological damage to plants than neutral salts (e.g., NaCl and Na2SO4) due to differences in pH. The mechanism by which plants respond to alkali stress is not fully understood, especially in plants having symbotic relat...
2018-07-27 | MTBLS481 | MetaboLights
ProteomicsO-GlcNAc proteome of invasive ductal breast carcinomas
O-GlcNAc proteins in LNM and non-LNM breast tumors of IDCs were identified by using the strategy of chemo-enzymatic labeling in combination with click chemistry and LC-MS/MS.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080753 | MassIVE
UnknownIdentification of a ubiquitin-protein ligase MaUPL6 modulating the response to Fusarium wilt in banana.
Not available
S-EPMC11796118 | biostudies-literature
TranscriptomicsRNA-seq of non coding RNA from serum exosomes of GC patients and healthy individuals
The dysregulation of exosomal microRNAs (miRNAs) play a crucial role in the development and progression of cancer. Differentially expressed miRNAs were identified in serum exosomes of GC patients and healthy individuals using next-generation sequencing and bioinformatics.
ORGANISM(S): Homo sapiens 
2023-11-01 | E-MTAB-12763 | biostudies-arrayexpress
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