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ProteomicsMiRNA-378a-5p attenuates the development of abdominal aortic aneurysm via ABLIM1-MKL1 signaling pathways
Abstract Objectives: Abdominal aortic aneurysm (AAA) is a fatal cardiovascular disease with no effective drug treatment currently available. The aberrant expressions of microRNAs (miRNAs) contribute to AAA pathogenesis. In this study, we aimed to perform miRNA microarray analysis to screen for diffe...
ORGANISM(S): Homo Sapiens 
2026-01-13 | PXD073033 |
ProteomicsGlobal profiling of the proteome and acetylome in mice with abdominal aortic aneurysms
Abdominal Aortic Aneurysm (AAA) is a fatal vascular disease characterized by abnormal expansion of the arterial wall and a high risk of rupture. Current treatments for AAA primarily rely on surgical intervention, while effective pharmacological therapies have yet to be developed. The major bottlenec...
ORGANISM(S): Mus Musculus 
2025-02-17 | PXD060895 |
ProteomicsProteomic Insights into Aprotinin’s Immunomodulatory Effects in Attenuating Renal Fibrosis in a Unilateral Ureteral Obstruction Model
Chronic kidney disease (CKD) is characterized by progressive renal fibrosis and immune dysregulation. Aprotinin, a broad-spectrum serine protease inhibitor, has shown dose-dependent effects on kidney function, but its role in chronic obstructive nephropathy remains unclear.
ORGANISM(S): Mus Musculus 
2025-05-03 | PXD063655 |
ProteomicsThe plasma DIA proteomic analysis for humans aimming at exploring the mechanism of RIPC’s protective effect under hypobaric hypoxia condition.
The plasma proteome profiling data come from the humans who received remote ischemic preconditioning treatment and experienced hypobaric hypoxia exposure then.
ORGANISM(S): Homo Sapiens 
2022-01-25 | PXD031247 |
ProteomicsProteomic analysis of hydrolase levels in the lysosomes from macrophages stimulated with or without LPS via LC_MS
Proteomic analysis of hydrolase levels in the lysosomes from macrophages stimulated with or without LPS via liquid chromatography–mass spectrometry (LC-MS), highlighting the expected LPS-induced increase in accumulation of proteases, ribonucleases (RNase) and other hydrolases.
ORGANISM(S): Mus Musculus 
2024-10-14 | PXD056776 |
ProteomicsDegradation analysis of SARS-CoV-2 proteins after incubation with h-lysoTRAP based on the proteomics data
To investigate the degradation activity of proteases inside lysosomal "TRAP", we conducted proteomic analysis of lysosomal "TRAP" with trapped authentic SARS-CoV-2.
ORGANISM(S): Severe Acute Respiratory Syndrome Coronavirus 2 
2024-10-15 | PXD056801 |
ProteomicsDetection of residual peptides of SARS-CoV-2 peptide after a 24-hour co-incubation with h-lysoTRAP via proteomic analysis
To gain a deeper insight into the residual SARS-CoV-2 peptides after degradation, we directly detected fragments (lower than 10 (kilodalton) kDa) of degraded SARS-CoV-2 via LC-MS, and overlapped these with the 3D crystal structure of SARS-CoV-2 proteins.
ORGANISM(S): Severe Acute Respiratory Syndrome Coronavirus 2 
2024-10-18 | PXD056987 |
ProteomicsDegradation analysis of SARS-CoV-2 proteins by h-lysoTRAP
To investigate the degradation activity of proteases inside lysosomal "TRAP", we conducted proteomic analysis of lysosomal "TRAP" with trapped authentic SARS-CoV-2.
ORGANISM(S): Severe Acute Respiratory Syndrome Coronavirus 2 
2024-10-18 | PXD056985 |
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