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TranscriptomicsYap and Taz in Neural Crest play a Crucial Role in Smooth Muscle Development
We conditionally knocked out both Yap and Taz in cranial neural crest (CNC) using the Wnt1Cre driver and sequenced mRNA from embryonic day 10.5 mandibles. Examination of mRNA level in E10.5 mandibular tissues from control and Wnt1Cre Taz and Yap dKO mutant.
ORGANISM(S): Mus musculus 
2016-03-01 | E-GEOD-69311 | biostudies-arrayexpress
ProteomicsEndothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2
Activation of endothelial YAP/TAZ signaling is crucial for physiological and pathological angiogenesis. The mechanisms of endothelial YAP/TAZ regulation are, however, incompletely understood. Here we report that the protocadherin FAT1 acts as a critical upstream regulator of endothelial YAP/TAZ whic...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-02-14 | MSV000091279 | MassIVE
ProteomicsMuscle stems cell LC-MS - Common and Distinctive Functions of the Hippo Effectors Taz and Yap in Skeletal Muscle Stem Cell Function
Abstract Hippo pathway downstream effectors Yap and Taz play key roles in cell proliferation and regeneration, regulating gene expression especially via interaction with Tead transcription factors. To investigate their role in skeletal muscle stem cells, we analysed Taz in vivo and ex vivo in compar...
ORGANISM(S): Mus musculus (Mouse) 
2017-06-13 | PXD005751 | Pride
Taz Muscle Yap 
GenomicsTead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition (ChIP-seq)
Cellular changes during an epithelial-mesenchymal transition (EMT) largely rely on global changes in gene expression orchestrated by transcription factors. Tead transcription factors and their co-factors Yap and Taz have been shown to be implicated in EMT, nevertheless, their direct target genes dur...
ORGANISM(S): Mus musculus 
2014-03-12 | E-GEOD-55709 | biostudies-arrayexpress
TranscriptomicsA YAP/TAZ-Regulated Molecular Signature is Associated with Oral Squamous Cell Carcinoma
Oral squamous cell carcinoma (OSCC) is a prevalent form of cancer that develops from the epithelium of the oral cavity. OSCC is on the rise worldwide, and death rates associated with the disease are particularly high. Despite progress in understanding of the mutational and expression landscape assoc...
ORGANISM(S): Homo sapiens 
2015-05-26 | E-GEOD-66949 | biostudies-arrayexpress
TranscriptomicsTead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition (expression)
Cellular changes during an epithelial-mesenchymal transition (EMT) largely rely on global changes in gene expression orchestrated by transcription factors. Tead transcription factors and their co-factors Yap and Taz have been shown to be implicated in EMT, nevertheless, their direct and indirect tar...
ORGANISM(S): Mus musculus 
2014-03-12 | E-GEOD-55710 | biostudies-arrayexpress
TranscriptomicsThe effect of YAP/TAZ knockdown on the intestinal epithelium
The Hippo pathway plays a crucial in organ size control during development and tissue homeostasis in adult life. To examine a role for Hippo signaling in the intestinal epithelium, we analyzed gene expression patterns in the mouse intestinal epithelilum transfected with siRNAs or expression plasmids...
ORGANISM(S): Mus musculus 
2014-07-18 | E-GEOD-45155 | biostudies-arrayexpress
GenomicsWidespread association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth [ChIP-Seq]
The goal of this study was to identify YAP/TAZ direct transcriptional targets and transcriptional partners, through ChIP-sequencing and gene expression profiling. ChIP-seq analysis of YAP, TAZ, TEAD4 and JUN in MDA-MB-231 cells. Two independent replicates were analysed for each TF, as well as for ne...
ORGANISM(S): Homo sapiens 
2015-08-03 | E-GEOD-66081 | biostudies-arrayexpress
TranscriptomicsThe transcriptional regulators TAZ and YAP direct Transforming Growth Factor-beta-induced tumorigenic phenotypes in breast cancer cells
Uncontrolled Transforming growth factor-beta (TGFβ) signaling promotes aggressive metastatic properties in late-stage breast cancers. However, how TGFβ-mediated cues are directed to induce late-stage tumorigenic events is poorly understood, particularly given that TGFβ has clear tumor suppressing ac...
ORGANISM(S): Homo sapiens 
2014-04-02 | E-GEOD-56445 | biostudies-arrayexpress
Proteomicsα-Catenin Levels Determine Direction of YAP/TAZ Response to Autophagy Perturbation
The factors regulating cellular identity are critical for understanding the transition from health to disease and responses to therapies. Cell identity is generally assigned based on static phenotypes, like “omics” profiles. However, how such static features translate into dynamic responses to pertu...
ORGANISM(S): Homo sapiens (Human) 
2021-03-19 | PXD023711 | Pride
Autophagy Α-catenin Yap/taz 
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