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TranscriptomicsLooking for mitochondrial associated RNA
We investigated the peripheral mitochondrial localization of nuclear-encoded mRNAs (MLR) in various conditions in which translation was inhibited or the mRNA binding protein context altered (Delta puf3). We used cell fractionation protocols together with microarray to assess the distribution of mRNA...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-01 | E-GEOD-9393 | biostudies-arrayexpress
TranscriptomicsComparative analysis of transcripts from mia40-4int mutant and wild-type Saccharomyces cerevisiae strains quantified in RNA-seq experiment
The vast majority of the mitochondrial proteome originates from nuclear genes and is transported into the organelle after synthesis in the cytosol. Complex machineries, which maintain the specificity of protein import and sorting exist. Dysfunctions of mitochondrial protein sorting pathways result i...
ORGANISM(S): Saccharomyces cerevisiae 
2015-07-31 | E-MTAB-3588 | biostudies-arrayexpress
TranscriptomicsATFS-1 mediates a protective transcription program during mitochondrial stress
ATFS-1 has been shown to regulate transcription of mitochondrial chaperone genes such as mtHsp70/hsp-6 and hsp-60 in response to mitocondrial stress. To identify the entire ATFS-1-mediated response, we compared the transcript profiles from wild-type and atfs-1(tm4525) worms raised in the absence and...
ORGANISM(S): Caenorhabditis elegans 
2012-07-11 | E-GEOD-38196 | biostudies-arrayexpress
ProteomicsThe metabolite-controlled ubiquitin conjugase Ubc8 promotes mitochondrial protein import by enhancing assembly of the TOM complex - DATA SET II
Mitochondria are essential organelles that play a key role in energy metabolism. Transitions between glycolytic and respiring conditions induce considerable adaptations of the cellular proteome. These metabolism-dependent changes are particularly pronounced for the protein composition of mitochondri...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-10-15 | PXD036508 | Pride
Mitochondrial import Ubc8 Yeast metabolism 
GenomicsMitochondrial protein import clogging as a mechanism of disease
Mitochondrial protein import clogging as a mechanism of disease
PRJNA944597 | ENA
ProteomicsThe metabolite-controlled ubiquitin conjugase Ubc8 promotes mitochondrial protein import by enhancing assembly of the TOM complex - Data Set 2
Mitochondria are essential organelles that play a key role in energy metabolism. Transitions between glycolytic and respiring conditions induce considerable adaptations of the cellular proteome. These metabolism-dependent changes are particularly pronounced for the protein composition of mitochondri...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-10-15 | PXD033193 | Pride
Mitochondrial import Metabolic switch 
ProteomicsMitoStores: Chaperone-controlled protein granules store mitochondrial precursors in the cytosol - Data Set 2: Hsp104 AP-MS
Hundreds of mitochondrial precursor proteins are synthesized in the cytosol and imported into mitochondria in a post-translational reaction. The early stages in mitochondrial protein targeting are poorly understood. Here we show that in baker’s yeast, the cytosol has the capacity to transiently stor...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-10-15 | PXD035762 | Pride
Mitostores Mitochondrial import Hsp104 
ProteomicsThe Orf9b protein of SARS-CoV-2 modulates mitochondrial protein biogenesis - Yeast Data Set
Viruses often induce a complex rewiring of cellular physiology to maximize their propagation. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) expresses high amounts of the viral antagonistic protein Orf9b. Increased amounts and mutated versions of Orf9b were found to correlate with ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-08-30 | PXD039850 | Pride
Orf9b Mitochondrial import 
TranscriptomicsmitoCPR - a surveillance pathway that protects mitochondria in response to mitochondrial import stress [yeast]
Mitochondrial functions are essential for cell viability and rely on protein import into the organelle. Physiological perturbations and disease conditions can lead to mitochondrial import defect. We find that in budding yeast, mitochondrial import defects result in activation of a surveillance mecha...
ORGANISM(S): Saccharomyces cerevisiae 
2019-03-16 | GSE96727 | GEO
ProteomicsA priority code in mitochondrial presequences - Data set 1: IPs from rabbit reticulocyte lysates
The biogenesis of mitochondria relies on the import of hundreds of different precursor proteins from the cytosol. Most of these proteins are synthesized with N-terminal presequences which serve as matrix targeting signals. Presequences consistently form amphipathic helices, but they considerably dif...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-07-09 | PXD053210 | Pride
Yeast mitochondrial import 
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