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ProteomicsWNT7 Promotes Proliferation of Pancreatic Progenitor Cells Differentiated from Human Pluripotent Stem Cells through Non-Canonical Wnt Signaling Pathway
A small molecule, AT7867, promotes proliferation of human pluripotent stem cell-derived pancreatic progenitor cells (PPCs), yet detailed mechanisms of its proliferative effect were not fully understood. Here, we performed cell-based siRNA screening on a subset of genes to reveal that WNT7B is a grow...
ORGANISM(S): Homo Sapiens (human) 
2022-03-27 | PXD018222 | JPOST Repository
ProteomicsWNT7 Promotes Proliferation of Pancreatic Progenitor Cells Differentiated from Human Pluripotent Stem Cells through Non-Canonical Wnt Signaling Pathway
A small molecule, AT7867, promotes proliferation of human pluripotent stem cell-derived pancreatic progenitor cells (PPCs), yet detailed mechanisms of its proliferative effect were not fully understood. Here, we performed cell-based siRNA screening on a subset of genes to reveal that WNT7B is a grow...
ORGANISM(S): Homo Sapiens (human) 
2021-07-01 | PXD018221 | JPOST Repository
UnknownMechanisms of the Jian Pi Tiao Gan Yin in the treatment of simple obesity revealed by network pharmacology.
Not available
S-EPMC9011268 | biostudies-literature
TranscriptomicsM. tuberculosis Rv3263 Knockout
We determine gene expression profile for the knockout of Rv3263 (DNA Methyltransferase) and compared to wildtype M. tuberculosis. Two RNA-Seq datasets are included: wildtype (H37Rv_SS1) and knockout (delta_Rv3263)
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2013-11-21 | E-GEOD-52551 | biostudies-arrayexpress
UnknownTransplantation of a beating heart: A first in man.
Not available
S-EPMC9019404 | biostudies-literature
GenomicsEvolutionary comparison of CTCF and YY1 binding in primate lymphoblastoid cell lines
We performed an evolutionary comparison of the binding of the TF CTCF in human, chimpanzee, gorilla, orang-utan, macaque, baboon and marmoset using lymphoblastoid cell lines (LCLs). We also probes YY1 binding in human, chimpanzee, orang-utan and baboon LCLs as well as human and mouse liver.
ORGANISM(S): Pan troglodytes 
2013-11-20 | E-MTAB-1511 | biostudies-arrayexpress
TranscriptomicsmiR-134/487b/655 Cluster regulates TGF-M-NM-2-induced epithelial-mesenchymal transition and drug resistance to Gefitinib by targeting MAGI2 in lung adenocarcinoma cells.
Epithelial-mesenchymal transition (EMT) has recently been recognized as a key element of cell invasion, migration, metastasis, and drug resistance in several types of cancer, including non-small cell lung cancer (NSCLC). Our aim was to clarify microRNA (miRNA) -related mechanisms underlying EMT foll...
ORGANISM(S): Homo sapiens 
2013-10-30 | E-GEOD-51828 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling of Macaca mulatta intact duodenum samples following chronic Delta9 Tetrahydrocannabinol (M-NM-^T9-THC) treatment to SIV infected rhesus macaques
The study describes miRNA expression in intact duodenum following chronic delta 9 tetrahydrocannabinol (M-NM-^T9-THC) administration to SIV-infected rhesus macaques. Chronic M-NM-^T9-THC administration to uninfected macaques significantly and positively modulated intestinal miRNA expression by incre...
ORGANISM(S): Macaca mulatta 
2014-11-19 | E-GEOD-61654 | biostudies-arrayexpress
TranscriptomicsThe Mycobacterium tuberculosis ECF sigma Factor sE: role in global gene expression and survival in macrophages
In previously published work, we identified three Mycobacterium tuberculosis sigma (s) factor genes responding to heat shock (sigB, sigE and sigH ). Two of them (sigB and sigE ) also responded to SDS exposure. As these responses to stress suggested that the s factors encoded by these genes could be ...
ORGANISM(S): Mycobacterium tuberculosis 
2007-08-02 | E-GEOD-8664 | biostudies-arrayexpress
TranscriptomicsPhasevarion mediated random switching of gene expression in Helicobacter Pylori
Many host-adapted bacterial pathogens contain DNA methyltransferases (mod genes) that are subject to phase-variable expression (high-frequency reversible ON/OFF switching of gene expression). In Haemophilus influenzae, Neissera Meningtidis and Neisseria Gonorrhoeae, the random switching of the modA ...
ORGANISM(S): Helicobacter pylori P12 
2012-01-16 | E-GEOD-26759 | biostudies-arrayexpress
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