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ProteomicsSecretome analysis of Human Umbilical Vein Endothelial Cells with PMA treatment using gel-LC-MS/MS
Secretome analysis of Human Umbilical Vein Endothelial Cells with PMA treatment using gel-LC-MS/MS
ORGANISM(S): Homo sapiens (Human) 
2013-09-09 | PRD000733 | Pride
ProteomicsAortic extracellular space components
THORACIC AORTA GUANIDINE EXTRACT
ORGANISM(S): Homo sapiens (Human) 
2012-07-20 | PRD000269 | Pride
ProteomicsMyofilament - Proteomics analysis of the cardiac myofilament subproteome reveals dynamic alterations in phosphatase subunit distribution
Rat skinned cardiomyocytes
ORGANISM(S): Rattus norvegicus (Rat) 
2011-04-15 | PRD000165 | Pride
ProteomicsHUVEC Secretome FFE - Proteomic analysis of the secretome of human umbilical vein endothelial cells using a combination of free-flow electrophoresis and nanoflow LC-MS/MS
Not available
ORGANISM(S): Homo sapiens (Human) 
2010-04-29 | PRD000108 | Pride
ProteomicsSFX-01 is therapeutic against myeloproliferative disorders caused by activating mutations in Shp2
Activating mutations of Src homology-2 domain-containing protein tyrosine phosphatase-2 (Shp2) cause multiple childhood conditions for which there is an unmet therapeutic need, including juvenile myelomonocytic leukemia (JMML) and Noonan syndrome. Using unbiased proteomics, the protein targets of SF...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-13 | PXD061882 | Pride
Sulforaphane Homology 2 containing protein tyrosine phosphatase 2 Juvenile myelomonocytic leukemia 
ProteomicsProteomic analyses reveal that loss of TDP-43 affects RNA processing and intracellular transport
Transactive response DNA-binding protein 43 (TDP-43) is a predominantly nuclear, ubiquitously expressed RNA and DNA-binding protein. It recognises and binds to UG repeats and is involved in pre-mRNA splicing, mRNA stability and microRNA metabolism. TDP-43 is essential in early embryonic development ...
ORGANISM(S): Homo sapiens (Human) 
2015-06-29 | PXD001668 | Pride
Intracellular transport Tdp-43 Comparative proteomics Amyotrophic lateral sclerosis Frontotemporal lobar degeneration Ranbp1 
ProteomicsInhibition of miR-199a-3p in a murine hypertrophic cardiomyopathy (HCM) model attenuates fibrotic remodeling
Background: Hypertrophic cardiomyopathy (HCM) is an autosomal dominant genetic disorder, characterized by cardiomyocyte hypertrophy, cardiomyocyte disarray and fibrosis, which has a prevalence of ~1:200-500 and predisposes individuals to sudden death and heart failure. The mechanisms through which d...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD042904 | Pride
Proteomics Micro rna Cardiac fibroblast Secretome 
ProteomicsRedox-state of pentraxin 3 as a novel biomarker for resolution of inflammation and survival in sepsis
In an endotoxaemic mouse model of sepsis, a tissue-based proteomics approach for biomarker discovery identified long pentraxin 3 (PTX3) as the lead candidate for inflamed myocardium. PTX3 accumulated as an octamer due to disulphide-bond formation in heart, kidney and lung ?common organ dysfunctions ...
ORGANISM(S): Mus musculus (Mouse) 
2014-07-01 | PXD001020 | Pride
Biomarkers  host-pathogen interaction  inflammatory response  prognostic markers  protein modification  serum/plasma 
ProteomicsECM characterization of aortas from Adamts5+/+ and Adamts5∆cat AngII-treated mice by LC-MS/MS
Objective - Thoracic aortic aneurysm (TAA), a degenerative disease of the aortic wall, is accompanied by changes in the structure and composition of the aortic extracellular matrix (ECM). The ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family has recently been implicated ...
ORGANISM(S): Mus musculus (Mouse) 
2018-05-08 | PXD009410 | Pride
Aneurysm Protease Ascending aorta Extracellular matrix Lc-ms/ms Adamts 
ProteomicsProtein aggregation is an early manifestation of phospholamban p.(Arg14del)-related cardiomyopathy
Background: The p.(Arg14del) pathogenic variant (R14del) of the phospholamban (PLN) gene is a prevalent cause of cardiomyopathy with heart failure. The exact underlying pathophysiology is unknown, and a suitable therapy is unavailable. We aim to identify molecular perturbations underlying this cardi...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-03 | PXD024594 | Pride
Inherited cardiomyopathy Heart failure Phospholamban Protein aggregation 
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