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ProteomicsA Stress-Adaptive Lipid Kinase Axis Defines Metabolic Vulnerabilities in Neuroendocrine Prostate Cancer
Neuroendocrine prostate cancer (NEPC) persists in a profoundly hypoxic microenvironment, yet the mechanisms enabling tumor adaptation to this metabolically challenging niche remain undefined. Here, we identify the lipid kinase PIKfyve as overexpressed in NEPC, functioning as a central node in a stre...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD076640 | Pride
UnknownPPIC-labeled CAFs: Key players in neoadjuvant chemotherapy resistance for gastric cancer.
Not available
S-EPMC11362775 | biostudies-literature
TranscriptomicsMiRNA expression profile in murine advanced atherosclerotic plaque compared with early atherosclerotic plaque
Aberrantly expressed miRNAs contribute to developmental abnormalities and diseases such as cancer, diabetes, and cardiovascular disorders, by hybridizing to specific mRNA targets and repressing their translation into proteins. Although miRNA expression signature is characterized in the process of ne...
ORGANISM(S): Mus musculus 
2013-03-27 | E-GEOD-34647 | biostudies-arrayexpress
TranscriptomicsMiRNA expression profile in murine advanced atherosclerotic plaque compared with un-diseased arterial wall
Aberrantly expressed miRNAs contribute to developmental abnormalities and diseases such as cancer, diabetes, and cardiovascular disorders, by hybridizing to specific mRNA targets and repressing their translation into proteins. Although miRNA expression signature is characterized in the process of ne...
ORGANISM(S): Mus musculus 
2013-03-27 | E-GEOD-34644 | biostudies-arrayexpress
TranscriptomicsMiRNA expression profile in murine early atherosclerotic plaque compared with un-diseased arterial tissue
Aberrantly expressed miRNAs contribute to developmental abnormalities and diseases such as cancer, diabetes, and cardiovascular disorders, by hybridizing to specific mRNA targets and repressing their translation into proteins. Although miRNA expression signature is characterized in the process of ne...
ORGANISM(S): Mus musculus 
2013-03-27 | E-GEOD-34645 | biostudies-arrayexpress
TranscriptomicsMiRNA expression profile in murine un-diseased arterial tissue on 3 month high fat diet vs 10 month high fat diet
Aberrantly expressed miRNAs contribute to developmental abnormalities and diseases such as cancer, diabetes, and cardiovascular disorders, by hybridizing to specific mRNA targets and repressing their translation into proteins. Although miRNA expression signature is characterized in the process of ne...
ORGANISM(S): Mus musculus 
2013-03-27 | E-GEOD-34646 | biostudies-arrayexpress
TranscriptomicsHuman Hepatocytes with Drug Metabolic Function Induced from Fibroblasts by Lineage Reprogramming
We generated induced human hepatocyte by transduction of several lineage specific transcription factors and analyzed the gene expression profile of generated hepatocytes and freshly isolated human hepatocytes through RNA sequencing. Global gene expression profile analysis
ORGANISM(S): Homo sapiens 
2014-03-10 | E-GEOD-54066 | biostudies-arrayexpress
TranscriptomicsMiR expression profiles in M1-polarized compared with unstimulated (MФ) bone marrow-derived macrophage cells
The global change of the miR expression profile during atherosclerosis is due to the infiltration of different types of leukocytes into the arterial vessel wall in addition to disease-specific regulation in vascular cells. Monocyte-derived macrophage accumulation in the subintimal region is critical...
ORGANISM(S): Mus musculus 
2012-12-26 | E-GEOD-33453 | biostudies-arrayexpress
TranscriptomicsMiR expression profile in M1-polarized bone marrow derived macrophage cells compared with normal mouse aortic tissue.
The global change of the miR expression profile during atherosclerosis is due to the infiltration of different types of leukocytes into the arterail vessel wall in addition to disease-specific regulation in vascular cells. Monocyte-derived macrophage accumulation in the subintimal region is critical...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-26556 | biostudies-arrayexpress
ProteomicsPan-analysis of Single Amino-acid Polymorphism
Uncovering dark mass in population proteomics: Pan-analysis of Single Amino-acid Polymorphism (Pan-SAP) revealed quantitative relevance with cognition and aging
ORGANISM(S): Homo Sapiens 
2024-12-31 | PXD059327 |
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