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ProteomicsProteomic analysis of differentially expressed proteins in the serum of patients with acute renal allograft rejection using iTRAQ labelling technology
Transplantation is currently the best treatment option for end-stage renal disease (ESRD) patients. However, acute rejection (AR) is the main source of failure in renal transplantation. The current gold standard for diagnosis of AR involves renal biopsy, but it is invasive, time consuming, costly an...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD015336 | Pride
Proteomics Acute rejection Serum Renal allograft Itraq 
ProteomicsGenotyping, generation and lysine 2-hydroxyisobutyrylation identification of the first human autosomal dominant osteopetrosis type II specific induced pluripotent stem cells
Background: Autosomal dominant osteopetrosis type II (ADO2) is a rare human genetic disease that has been broadly studied as an important osteopetrosis model; however, there are no disease-specific induced pluripotent stem cells (ADO2-iPSCs) that may be valuable for understanding the pathogenesis an...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD014227 | Pride
Osteopetrosis Whole exome sequencing Ipscs 2-hydroxyisobutyrylation Clcn7 
UnknownComparative transcriptome analysis of molecular mechanisms underlying adventitious root developments in Huangshan Bitter tea (Camellia gymnogyna Chang) under red light quality.
Not available
S-EPMC10070859 | biostudies-literature
ProteomicsMultiplex analyses of mitochondria in colorectal cancer patients uncover novel diagnostic and therapeutic opportunities
Background: Multi-omics analyses are profitable for discovering novel biomarkers and drug targets, but such integrated examinations on mitochondria of colorectal cancer (CRC) patients are lacking. Methods: We investigated global structural variants, DNA methylation, chromatin accessibility, proteom...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021318 | Pride
Mitochondria  multi-omics  colorectal cancer  prognosis  drug targets 
ProteomicsMultiplex analyses of mitochondria in colorectal cancer patients uncover novel diagnostic and therapeutic opportunities
Background: Multi-omics analyses are profitable for discovering novel biomarkers and drug targets, but such integrated examinations on mitochondria of colorectal cancer (CRC) patients are lacking. Methods: We investigated global structural variants, DNA methylation, chromatin accessibility, proteom...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021314 | Pride
Mitochondria  multi-omics  colorectal cancer  prognosis  drug targets 
ProteomicsProteome analysis of lysine 2-hydroxyisobutyrylation in the peripheral blood of systemic lupus erythematosus patients
Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects multiple organs. Protein lysine modifications play important roles in gene regulation, transcription, metabolism and other biological processes. The lysine 2-hydroxyisobutyrylation(Khib) histone mark has recently been di...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD015351 | Pride
Sle  2-hydroxyisobutyrylation  mass spectrometry  bioinformatics 
ProteomicsA proteomic analysis of lysine crotonylation in systemic lupus erythematosus patients
Posttranslational modification (PTM) refers to the process of the covalent processing of translated proteins, as well as the activities and functions of proteins, and it is involved in almost all cellular pathways and processes. Lysine crotonylation (Kcr) is a recently identified PTM and plays a key...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD012966 | Pride
Posttranslational modification Lysine crotonylation Lc-ms/ms 
ProteomicsIntegrating multi-omics analyses unveil protein features of gestational diabetes mellitus and preeclampsia
As one of the most common maternal comorbidities, gestational diabetes mellitus (GDM) and preeclampsia (PE) are associated with maternal and infant health. Although the pathogenesis of PE and GDM remains controversial, oxidative stress is thought to be involved in the underlying pathology of GDM and...
ORGANISM(S): Homo sapiens (Human) 
2024-01-25 | PXD032981 | Pride
Lysine acetylation Proteomics Gestational diabetes mellitus Preeclampsia Oxidative stress 
ProteomicsA qualitative proteome-wide lysine crotonylation profiling reveals protein modification alteration in the leukocyte extravasation pathway in systemic lupus erythematosus
Background Systemic lupus erythematosus (SLE) is a severe systemic autoimmune disease with multiple manifestations. Lysine crotonylation (Kcr) is a newly discovered post-translational modification (PTM) epigenetic pattern which may affect gene expression and linked to diseases causally. Methods We ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042217 | Pride
Systemic lupus erythematosus  proteome  crotonylation  post-translational modifications  leukocyte extravasation 
ProteomicsQuantitative proteomic analyses to reveal the key features of proteins in new onset Ankylosing spondylitis patients
Ankylosing spondylitis (AS) is a chronic immune-mediated disease. Various immune cells play an essential role in the AS pathogenesis. However, the specific pathogenesis of AS has not been well understood. Proteomic profiles of peripheral blood mononuclear cells (PBMCs) were applied to reveal the spe...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019667 | Pride
Ankylosing spondylitis  peripheral blood mononuclear cells  proteomic  phosphoromics 
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