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TranscriptomicsGenomic analysis of hESC pedigrees enables identification of de novo genetic alterations and determination of the timing and origin of mutational events
Given the association between mutational load and cancer, the observation that genetic aberrations are frequently found in human pluripotent stem cells (hPSCs) is of concern. Prior studies in hiPSCs have shown that deletions and regions of loss-of-heterozygosity (LOH) tend to arise during reprogramm...
ORGANISM(S): Homo sapiens 
2014-04-21 | E-GEOD-49452 | biostudies-arrayexpress
UnknownGenomic analysis of hESC pedigrees identifies de novo mutations and enables determination of the timing and origin of mutational events.
Not available
S-EPMC3894204 | biostudies-literature
UnknownStabilization of hESCs in two distinct substates along the continuum of pluripotency.
Not available
S-EPMC9668692 | biostudies-literature
UnknownBlastomere biopsy for PGD delays embryo compaction and blastulation: a time-lapse microscopic analysis.
Not available
S-EPMC5125156 | biostudies-literature
UnknownTime-lapse imaging reveals delayed development of embryos carrying unbalanced chromosomal translocations.
Not available
S-EPMC6420524 | biostudies-literature
ProteomicsSkin Exposure to UVB Light induces a Skin-Brain-Gonad Axis and Sexual Behavior
Ultraviolet (UV) light affects endocrinological and behavioral aspects of human sexuality via an unknown mechanism. Using a unique male-female comparative approach, we discovered that the sexual behavioral and hormonal features enhanced by UVB are mediated by the skin. In mice, UV exposure increases...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD025973 | Pride
Proteomics Uvb light Sexual behavior 
UnknownSkin exposure to UVB light induces a skin-brain-gonad axis and sexual behavior.
Not available
S-EPMC8411113 | biostudies-literature
UnknownIsoform-resolved transcriptome of the human preimplantation embryo.
Not available
S-EPMC10616205 | biostudies-literature
UnknownPrinciples of signaling pathway modulation for enhancing human naive pluripotency induction.
Not available
S-EPMC8423434 | biostudies-literature
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