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MetabolomicsEffect of short-term use of FFP2 (N95) masks on the salivary metabolome of young healthy volunteers: a pilot study.
The use of face masks has become an integral part of public life in the post-pandemic era. However, the understanding of the effect of wearing masks on physiology remains incomplete and is required for informing public health policies. For the first time, we report the effects of wearing FFP2 masks ...
2024-08-07 | MTBLS5803 | MetaboLights
MetabolomicsPostprandial Metabolism is Impaired in Overweight Normoglycemic Young Adults without Family History of Diabetes

While the risk factors for Type 2 diabetes (T2DM) are known, early predictive markers of transition from normal to a prediabetes state are unidentified. We studied the basal metabolism and metabolic response to a mixed-meal challenge in 110 healthy subjects in the age group of 18 to 40 years (Mal...

2019-03-14 | MTBLS743 | MetaboLights
MetabolomicsFaecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients

BACKGROUND: The gut-brain axis and the intestinal microbiota are emerging as key players in health and disease. Shifts in intestinal microbiota composition affect a variety of systems, however, evidence of their direct impact on cognitive functions is still lacking. We tested whe...

2021-12-17 | MTBLS1437 | MetaboLights
MetabolomicsAcute response to a high-saturated, high-refined carbohydrate meal in healthy young men shows novel perturbation of multiple metabolic and defense pathways

Regular consumption of fat and refined carbohydrates induces metabolic stress, increasing chronic metabolic disease risk. In healthy volunteers, we characterised the response to a high-fat/high-carbohydrate meal (HFHCM), typical of an ultra-processed food, by proteomic and metabolomics analyses, ...

2026-04-02 | MTBLS10972 | MetaboLights
MetabolomicsAge-related differences in the gut microbiota and plasma metabolome in dogs: a prospective cross-sectional study under standardized dietary conditions
Background: Aging is associated with progressive metabolic and physiological changes that influence health span in humans and may similarly impact dogs. This study aimed to characterize in the gut microbiota and their associations with host metabolism. Client-owned young adult (2-5 years, > 20 kg, n...
2026-06-26 | MTBLS14861 | MetaboLights
MetabolomicsHepatic [U-13C]Lactate tracing and metabolomics in young and old WT and SIRT6 overexpressing mice
Not available
ORGANISM(S): Mus musculus 
ST001507 | MetabolomicsWorkbench
MetabolomicsDiel metabolomics analysis of a hot spring chlorophototrophic microbial mat leads to new hypotheses of community member metabolisms
Dynamic environmental factors such as light, nutrients, salt, and temperature continuously affect chlorophototrophic microbial mats, requiring adaptive and acclimative responses to stabilize composition and function. Quantitative metabolomics analysis can provide insights into metabolite dynamics fo...
2024-02-23 | MTBLS187 | MetaboLights
MetabolomicsProteolethargy is a pathogenic mechanism in chronic disease

The pathogenic mechanisms of many diseases are well understood at the molecular level, but there are prevalent diseases associated with pathogenic signaling, such as diabetes and chronic inflammatory disorders, where our understanding is more limited. Here we report that pathogenic signaling supp...

2024-08-09 | MTBLS9535 | MetaboLights
TranscriptomicsA Parallel Study of mRNA and MicroRNA Profiling of Peripheral Blood in Young Adult Women (MicroRNA Profiling)
The goal of this study is to identify aging-related biomarkers to improve our understanding of complex physiological changes, thereby providing a means to investigate the mechanism by which aging influences various diseases. Global microRNA expression patterns from peripheral blood of two groups of ...
ORGANISM(S): Homo sapiens 
2013-08-13 | E-GEOD-49837 | biostudies-arrayexpress
TranscriptomicsA Parallel Study of mRNA and MicroRNA Profiling of Peripheral Blood in Young Adult Women (mRNA Profiling)
The goal of this study is to identify aging-related biomarkers to improve our understanding of complex physiological changes, thereby providing a means to investigate the mechanism by which aging influences various diseases. Global gene expression patterns from peripheral blood of two groups of heal...
ORGANISM(S): Homo sapiens 
2013-08-13 | E-GEOD-49839 | biostudies-arrayexpress
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