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ProteomicsSystematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways
Pathogens deploy effector proteins to exploit host cell biology, yet most pathogen open reading frames (ORFs) are rapidly evolving and lack functional annotation. To address this, we developed the eORFeome, a scalable functional genomics platform encompassing 3,835 effector ORFs from diverse viruses...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD078568 | Pride
Pathogens Functional genomics Human signalling pathways Effectors Host-pathogen interaction Orfeome High-throughput screening 
ProteomicsThe human diabetes-specific visceral adipose tissue proteome: insights into mechanisms of adipose tissue dysfunction in metabolic disease
Introduction: The human adipose tissue proteome associated with type 2 diabetes (DM) is not well described. An understanding of the DM-specific adipose tissue proteome would provide insight into mechanisms underlying the pathogenesis of DM. Methods: We used label-free proteomics analysis to quanti...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-03-27 | MSV000085169 | MassIVE
ProteomicsSystematic Discovery of Pro- and Anti-HIV Host Factors in Primary Human CD4+ T Cells
Despite extensive efforts, significant gaps remain in our understanding of which host factors promote or restrict human immunodeficiency virus (HIV) infection in human CD4+ T cells. Here, we employed orthogonal genome-wide CRISPR activation (CRISPRa) and CRISPR knockout (CRISPRn) screens in primary ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD071892 | Pride
Host factor Ip-ms Ppi Pi16 Hiv Cd4+ t cells 
UnknownLarge-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci.
Not available
S-EPMC10335935 | biostudies-literature
UnknownClinical features and outcomes in carriers of pathogenic desmoplakin variants.
Not available
S-EPMC11745529 | biostudies-literature
UnknownDeformable templates guided discriminative models for robust 3D brain MRI segmentation.
Not available
S-EPMC5966025 | biostudies-literature
TranscriptomicsCopper exposures on the endangered delta smelt
The delta smelt (Hypomesus transpacificus) is an endangered pelagic fish species endemic to the Sacramento-San Joaquin estuary, California, and considered an indicator of ecosystem health. The experimental combination of molecular biomarkers with higher level condition indicators may allow for inter...
ORGANISM(S): Hypomesus transpacificus 
2010-08-18 | E-GEOD-23238 | biostudies-arrayexpress
UnknownGene content evolution in the arthropods.
Not available
S-EPMC6977273 | biostudies-literature
UnknownValidation of postoperative residual contrast-enhancing tumor volume as an independent prognostic factor for overall survival in newly diagnosed glioblastoma.
Not available
S-EPMC6071654 | biostudies-literature
UnknownTitin-related familial dilated cardiomyopathy: factors associated with disease onset.
Not available
S-EPMC12718689 | biostudies-literature
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