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TranscriptomicsGene expression data from temporal cortex of young adult, old and AD-like Microcebus murinus
Aging is the primary risk factor of neurodegenerative disorders such as Alzheimer's disease (AD). However, the molecular events occurring during brain aging are extremely complex and still largely unknown. For a better understanding of these age-associated modifications, animal models as close as po...
ORGANISM(S): Microcebus murinus 
2011-04-01 | E-GEOD-21779 | biostudies-arrayexpress
TranscriptomicsA Parallel Study of mRNA and MicroRNA Profiling of Peripheral Blood in Young Adult Women (MicroRNA Profiling)
The goal of this study is to identify aging-related biomarkers to improve our understanding of complex physiological changes, thereby providing a means to investigate the mechanism by which aging influences various diseases. Global microRNA expression patterns from peripheral blood of two groups of ...
ORGANISM(S): Homo sapiens 
2013-08-13 | E-GEOD-49837 | biostudies-arrayexpress
TranscriptomicsA Parallel Study of mRNA and MicroRNA Profiling of Peripheral Blood in Young Adult Women (mRNA Profiling)
The goal of this study is to identify aging-related biomarkers to improve our understanding of complex physiological changes, thereby providing a means to investigate the mechanism by which aging influences various diseases. Global gene expression patterns from peripheral blood of two groups of heal...
ORGANISM(S): Homo sapiens 
2013-08-13 | E-GEOD-49839 | biostudies-arrayexpress
TranscriptomicsmicroRNA expression in young and elder mouse tissues
We investigated expression profiles of miRNAs in various tissues of young and elder mice by means of DNA microarray. The results suggested that there was a difference in the expression of miRNAs between young and elder mice. Small RNA samples prepareed from various tissues of young and elder mice we...
ORGANISM(S): Mus musculus 
2012-11-01 | E-GEOD-34532 | biostudies-arrayexpress
TranscriptomicsThe Expression of MicroRNA and microRNA Clusters in the Aging Heart
Adult aging is a complex biological process associated with altered gene expression and a decline in physiological performance. The microRNAs have been implicated in cardiac development, cardiac hypertrophy and heart failure. However, the impact of adult aging on cardiac expression of both miRNA gui...
ORGANISM(S): Mus musculus 
2012-08-20 | E-GEOD-32935 | biostudies-arrayexpress
TranscriptomicsRNA immunoprecipitation of GLD-1 followed by microarray analysis of the co-IP'ed mRNAs
RNA-binding proteins (RBPs) are critical regulators of gene expression and elucidating the interactions of RBPs with their RNA targets is necessary to understand how combinations of RBPs control transcriptome expression. The Quaking-related (QR) sub-family of STAR domain RBPs includes developmental ...
ORGANISM(S): Caenorhabditis elegans 
2011-02-04 | E-GEOD-21591 | biostudies-arrayexpress
TranscriptomicsA Parallel Study of mRNA and MicroRNA Profiling of Peripheral Blood in Young Adult Women
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-08-13 | E-GEOD-30205 | biostudies-arrayexpress
TranscriptomicsMicroRNAs induced during response to stress in C. elegans
To understand how microRNAs are involved in stress response, we examined their expression changes in C. elegans animals that were exposed to stress conditions, including heat shock, oxidation, hypoxia and starvation. Total RNAs were purified from young adult animals that were exposed to each stress,...
ORGANISM(S): Caenorhabditis elegans 
2012-02-04 | E-GEOD-35529 | biostudies-arrayexpress
GenomicsGenome-wide DNA methylation changes in skeletal muscle between young and middle-aged pigs [methylation]
Background: Age-related physiological, biochemical and functional changes in mammalian skeletal muscle have been shown to begin at the mid-point of the lifespan. However, the underlying changes in DNA methylation that occur during this turning point of the muscle aging process have not been clarifie...
ORGANISM(S): Sus scrofa 
2014-08-02 | E-GEOD-50716 | biostudies-arrayexpress
GenomicsEpigenetic determinants of muscle stem cell quiescence and chronological aging (ChIP-seq)
Skeletal muscle is a post-mitotic tissue that exhibits an extremely low turnover in the absence of disease or injury. At the same time, muscle possesses remarkable regenerative capacity mediated by satellite cells (SCs) that reside in close association with individual myofibers, underneath the fiber...
ORGANISM(S): Mus musculus 
2013-08-13 | E-GEOD-47362 | biostudies-arrayexpress
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