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MetabolomicsIncreased fatty acid metabolism and decreased glycolysis are hallmarks of metabolic reprogramming within microglia in degenerating white matter during recovery from experimental stroke
The goal of this study was to evaluate changes in metabolic homeostasis during the first 12 weeks of recovery in a distal middle cerebral artery occlusion mouse model of stroke. To achieve this goal, we compared the brain metabolomes of ipsilateral and contralateral hemispheres from aged male mice u...
2022-10-06 | MTBLS5543 | MetaboLights
TranscriptomicsTRX-1 Regulates SKN-1 Nuclear Localization Cell Non-Autonomously in Caenorhabditis elegans
The Caenorhabditis elegans oxidative stress response transcription factor, SKN-1, is essential for the maintenance of redox homeostasis and is a functional ortholog of the Nrf family of transcription factors. The numerous levels of regulation that govern these transcription factors underscore their ...
ORGANISM(S): Caenorhabditis elegans 
2016-04-01 | E-GEOD-77976 | biostudies-arrayexpress
ProteomicsAcarbose improves late-life physical function in mice of both sexes, but rejuvenates cardiac structure and lipid profile in males only
With an expanding aging population burdened with comorbidities, there is considerable interest in treatments that optimize health in later life. Acarbose (ACA), a drug used clinically to treat Type 2 diabetes (T2DM) can extend mouse lifespan, with greater effect in males than in females. Utilizing a...
ORGANISM(S): Mus Musculus 
2021-03-03 | PXD017706 | panorama
ProteomicsProteomics analysis of human breast milk by two-dimensional polyacrylamide gel electrophoressi (2D-PAGE) coupled with mass spectrometry to assess breast cancer risk
Breast Cancer (BC) is one of the most common cancers and one of the most common causes for cancer- related mortality. Discovery of protein biomarkers associated with cancer, is considered as important for early diagnosis and prediction of the cancer risk. Protein biomarkers could be investigated by ...
ORGANISM(S): Homo sapiens (Human) 
2023-10-20 | PXD040188 | Pride
Breast cancer  breast milk  biomarkers  protein dysregulation  2d-page  proteomics  mass spec-trometry 
ProteomicsA SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Purposing
An outbreak of the novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 170,000 people since the end of 2019, killed over 7,400, and caused worldwide social and economic disruption. SARS-CoV-2 infection has a mortality rate of 3.4% among confirmed case...
ORGANISM(S): Homo sapiens (Human) 
2020-03-23 | PXD018117 | Pride
Sars-cov-2 Ppi Coronavirus Covid-19 
ProteomicsTransgenic hookworm secretes anti-tetrodotoxin human single chain antibody
We generated transgenic hookworms secreting anti-TTX countermeasure s16-HuScFv. Proteomics samples were generated from host hamster serum
ORGANISM(S): Ancylostoma Ceylanicum Mesocricetus Auratus 
2026-01-17 | PXD073224 |
ProteomicsCoronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication
Coronaviruses, including SARS-CoV-2, can cause severe disease in humans, whereas reservoir hosts like Rhinolophus bats appear to remain asymptomatic for reasons that are not well-recognized. To understand how host-specific protein-protein interactions (PPIs) shape infection outcomes, we generated co...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 Homo sapiens (Human) Bat coronavirus RaTG13 Severe acute respiratory syndrome coronavirus 2 
2026-06-29 | PXD065873 | Pride
Host-pathogen interactions Ratg13 Sars-cov-2 Apms Bats 
ProteomicsR.norvegicus - Cardiac ventricle, normalized spectral counts (Kaushiketal,scitranslmed2015)
abundance based on normalized spectral counts, Interaction consistency score: 7.5, Coverage: 4
ORGANISM(S): 10116 
2015-00-00 | 3976932592 | PAXDB
ProteomicsR.norvegicus - Cardiac ventricle, normalized spectral counts (Kaushiketal,scitranslmed2015)
abundance based on normalized spectral counts, Interaction consistency score: 6.6, Coverage: 4
ORGANISM(S): 10116 
2015-00-00 | 3650757554 | PAXDB
ProteomicsMmulatta - Cardiac ventricle, normalized spectral counts (Kaushiketal,scitranslmed2015)
abundance based on normalized spectral counts, Interaction consistency score: 2.2, Coverage: 4
ORGANISM(S): 9544 
2015-00-00 | 14227165 | PAXDB
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