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RNA-Seq was used to study alterations in gene expression in the developing human heart across three gestational ages in the first and early second trimester. All tissue was acquired following elective termination of pregnancy and informed parental consent. Storage and use of tissue was in premises l...
ORGANISM(S): Homo sapiens 
Osteosarcoma (OS) is the most common primary bone tumour in children and young adults, and the second highest cause of cancer-related death in this age group. In spite of aggressive chemotherapy, disease-free survival has not improved significantly in the past 20 years, and 50% of patients subsequen...
ORGANISM(S): Homo sapiens 
ChIP-Chip for T-bet and GATA-3 in human Th1 and Th2 cells, gene expression profiling of human Th1 and Th2 cells and of T-cells from T-bet-deficient mice,
ORGANISM(S): Homo sapiens 
Using EWS-FLI and its parental transcription factor, FLI1, we created a unique experimental system to address questions regarding the genomic mechanisms by which chimeric transcription factors cause cancer. We found that in tumor cells, EWS-FLI targets regions of the genome distinct from FLI1, despi...
ORGANISM(S): Homo sapiens 
Chromatin immunoprecipitation using H3K27Ac and H3K4me1 antibodies in Rex1GFPd2 mouse ES cells (parental line; E14Tg2a)
ORGANISM(S): Mus musculus 
Chromatin immunoprecipitation using Otx2 antibodies in Rex1GFPd2 mouse ES cells (parental line; E14Tg2a)
ORGANISM(S): Mus musculus 
Chromatin immunoprecipitation using anti-FOXM1 (Santa Cruz Biotechnology: sc- 502X) antibodies in an OE33 cell line
ORGANISM(S): Homo sapiens 
Assessed effect of DKK1 treatment on gene expression during the first four days of ES cell differentiation in serum containing medium.
ORGANISM(S): Mus musculus 
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