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TranscriptomicsA Parallel Study of mRNA and MicroRNA Profiling of Peripheral Blood in Young Adult Women (mRNA Profiling)
The goal of this study is to identify aging-related biomarkers to improve our understanding of complex physiological changes, thereby providing a means to investigate the mechanism by which aging influences various diseases. Global gene expression patterns from peripheral blood of two groups of heal...
ORGANISM(S): Homo sapiens 
2013-08-13 | E-GEOD-49839 | biostudies-arrayexpress
MetabolomicsAge-related differences in the gut microbiota and plasma metabolome in dogs: a prospective cross-sectional study under standardized dietary conditions
Background: Aging is associated with progressive metabolic and physiological changes that influence health span in humans and may similarly impact dogs. This study aimed to characterize in the gut microbiota and their associations with host metabolism. Client-owned young adult (2-5 years, > 20 kg, n...
2026-06-26 | MTBLS14861 | MetaboLights
TranscriptomicsRNAseq of whole ovarian follicles from young and old mice.
Compare gene expression in whole ovarian follicles from young (6-12 weeks) and old (14-17 months) mice. Whole follicles,consist of the oocyte and granulosa cells. As oocytes are very difficult to extract intact from old follicles due to fibrosis, whole follicles were sequenced instead, so that old...
ORGANISM(S): Mus musculus 
2018-05-22 | E-MTAB-5952 | biostudies-arrayexpress
TranscriptomicsA Parallel Study of mRNA and MicroRNA Profiling of Peripheral Blood in Young Adult Women
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-08-13 | E-GEOD-30205 | biostudies-arrayexpress
GenomicsGenome-wide DNA methylation changes in skeletal muscle between young and middle-aged pigs [methylation]
Background: Age-related physiological, biochemical and functional changes in mammalian skeletal muscle have been shown to begin at the mid-point of the lifespan. However, the underlying changes in DNA methylation that occur during this turning point of the muscle aging process have not been clarifie...
ORGANISM(S): Sus scrofa 
2014-08-02 | E-GEOD-50716 | biostudies-arrayexpress
MetabolomicsAging markers in human urine: A comprehensive, non-targeted LC-MS study
Summary Metabolites in human biofluids document individual physiological status. We conducted comprehensive, non-targeted, non-invasive metabolomic analysis of urine from 27 healthy human subjects, comprising 13 youths (30±3 yr) and 14 seniors (76±4 yr). Quantitative analysis of 99 metabolites revea...
2020-10-14 | MTBLS1407 | MetaboLights
MetabolomicsProteolethargy is a pathogenic mechanism in chronic disease

The pathogenic mechanisms of many diseases are well understood at the molecular level, but there are prevalent diseases associated with pathogenic signaling, such as diabetes and chronic inflammatory disorders, where our understanding is more limited. Here we report that pathogenic signaling supp...

2024-08-09 | MTBLS9535 | MetaboLights
TranscriptomicsEffect of acute creatine monohydrate supplementation on skeletal muscle transcriptome
Expression profiling of vastus lateralis muscle of young, healthy, non-obese men supplemented with creatine monohydrate vs. placebo for 10 days. Results identify transcriptional pathways activated in skeletal muscles as a result of acute creatine monohydrate supplementation. Keywords: Supplementatio...
ORGANISM(S): Homo sapiens 
2010-06-11 | E-GEOD-7877 | biostudies-arrayexpress
TranscriptomicsExpression changes in IC GABA receptors in the auditory midbrain of young adult and aging presbycusis mice.
We performed a microarray analysis of auditory midbrain (inferior colliculus, IC) mRNA from young adult CBA mice (controls) with good hearing, middle aged (MA) with good hearing, and old mild (MP) and severe (SP) presbycusic CBA mice. Fold Change data derived from RMA normalization revealed that the...
ORGANISM(S): Mus musculus 
2013-08-06 | E-GEOD-49522 | biostudies-arrayexpress
TranscriptomicsExpression data from Arabidopsis wild type and cdm1 young floral buds
We used microarray analysis to examine transcriptomic changes in cdm1 mutant, identifying genes potentially regulated by CDM1 by comparing gene expression between cdm1 and wild type young floral buds. Among 375 genes that showed differential expression (P-value <0.05) with >1.5-fold changes between ...
ORGANISM(S): Arabidopsis thaliana 
2014-03-11 | E-GEOD-55799 | biostudies-arrayexpress
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