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Background: Pulmonary Fibrosis (PF) is an interstitial lung disease of unknown etiology, characterized by excessive accumulation of extracellular matrix in the lungs, which disrupts the structure and gas exchange of the alveoli. There are only two approved therapies for PF, nintedanib (Nib) and pirf...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-10 | PXD024058 | Pride
Photoaging is cumulative damage that is caused by chronic, repeated solar radiation exposure to skin. Its molecular mechanisms are poorly understood at the level of global gene expression.This study set out to uncover genes and functional modules involved in photoaging at the level of transcription,...
ORGANISM(S): Homo sapiens 
Azeliragon for the treatment of Staphylococcus aureus proteome
ORGANISM(S): Staphylococcus Aureus 
2025-10-27 | PXD069935 |
To investigate the interactional proteins with TANGO6, we conducted MS.
ORGANISM(S): Homo Sapiens 
2024-02-04 | PXD049158 |
Background:Human aneuploidy is the leading cause of early pregnancy loss, mental retardation, and multiple congenital anomalies. Due to the high mortality associated with aneuploidy, the pathophysiological mechanisms of aneuploidy syndrome remain largely unknown. Previous studies focused mostly on w...
ORGANISM(S): Homo sapiens 
The leptotene-zygotene transition is a major step in meiotic progression during which pairing between homologous chromosomes is initiated and double strand breaks occur. OsAM1, a homolog of maize AM1 and Arabidopsis SWI1, encodes a protein with a coiled-coil domain in its central region that is requ...
ORGANISM(S): Oryza sativa Indica Group 
Proteomic analysis of carbapenem-resistant Klebsiella pneumoniae exposure to tigecycline and aminoglycosides
ORGANISM(S): Klebsiella Pneumoniae Subsp. Pneumoniae Hs11286 
2022-01-17 | PXD031030 |
The aim of the present study was to investigate the therapeutic mechanism of the anti-cholestatic effects of melatonin against ANIT-induced liver injury in rats, and to screen for potential biomarkers of cholestasis through isobaric tags for relative and absolute quantitation (iTRAQ) quantitative pr...
ORGANISM(S): Rattus Norvegicus 
2020-12-16 | PXD023155 |
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