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ProteomicsEnabling Photoactivated Cross-linking Mass Spectrometric Analysis of Protein Complexes by Novel MS-cleavable Cross-linkers
Cross-linking mass spectrometry (XL-MS) is a powerful tool for studying protein-protein interactions and elucidating architectures of protein complexes. While residue-specific XL-MS studies have been very successful, accessibility of interaction regions non-targetable by specific chemistries remain ...
ORGANISM(S): Bos taurus (Bovine) Saccharomyces cerevisiae (Baker's yeast) 
2021-05-07 | PXD022690 | Pride
26s proteasome Photocross-linking Sdaso Bsa 
UnknownBcl-xL DNAzymes promote radiosensitivity and chemosensitivity in colorectal cancer cells via enhancing apoptosis.
Not available
S-EPMC8817578 | biostudies-literature
UnknownChemosensitization of solid tumors by inhibition of Bcl-xL expression using DNAzyme.
Not available
S-EPMC4253417 | biostudies-literature
ProteomicsTrioxane-based MS-cleavable Cross-linking Mass Spectrometry for Profiling Multimeric Interactions of Cellular Networks
Here, we present a novel trioxane-based MS-cleavable homotrifunctional cross-linker TSTO, which can target three proximal lysine residues simultaneously. Owing to its unique structure and MS-cleavability, TSTO enables fast and unambiguous identification of cross-linked peptides using LC-MSn analysis...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-30 | PXD063825 | Pride
Tsto Xl-ms Lc-msn 
ProteomicsTrioxane-based MS-cleavable Cross-linking Mass Spectrometry for Profiling Multimeric Interactions of Cellular Networks
Here, we present a novel trioxane-based MS-cleavable homotrifunctional cross-linker TSTO, which can target three proximal lysine residues simultaneously. Owing to its unique structure and MS-cleavability, TSTO enables fast and unambiguous identification of cross-linked peptides using LC-MSn analysis...
ORGANISM(S): Homo sapiens (Human) 
2025-05-30 | PXD054551 | Pride
Tsto Xl-ms Cross-linking mass spectrometry 
UnknownProteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells.
Not available
S-EPMC7904819 | biostudies-literature
UnknownTumorigenicity decrease in Bcl-xL deficient MDCK cells ensuring the safety for influenza vaccine production.
Not available
S-EPMC11649150 | biostudies-literature
TranscriptomicsMcl-1 is a key determinant of breast cancer cell survival [expression]
mRNA expression profile of cultured Breast Cancer cell line measured by Affymetrix microarrays Whole genome expression profile of 32 breast cancer cell lines were analyzed with 3 biological replicates.
ORGANISM(S): Homo sapiens 
2015-08-07 | E-GEOD-66071 | biostudies-arrayexpress
TranscriptomicsMcl-1 is a key determinant of breast cancer cell survival [copy number]
Copy number profile of cultured Breast Cancer cell line measured by Affymetrix SNPs microarrays Whole genome copy number profile of 2 breast cancer cell lines were analyzed using Affymetrix SNP6.0 arrays
ORGANISM(S): Homo sapiens 
2015-08-07 | E-GEOD-66070 | biostudies-arrayexpress
UnknownDe novo pyrimidine biosynthesis inhibition synergizes with BCL-X<sub>L</sub> targeting in pancreatic cancer.
Not available
S-EPMC12311037 | biostudies-literature
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