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TranscriptomicsDirect Reprogramming of Human Neural Stem Cells by OCT4
Induced pluripotent stem (iPS) cells have been generated from mouse and human somatic cells by ectopic expression of the four transcription factors (OCT4, SOX2, c-MYC, KLF4). We previously reported that Oct4 alone is sufficient to directly reprogram adult mouse neural stem cells (NSCs) to iPS cells....
ORGANISM(S): Homo sapiens 
2010-05-20 | E-GEOD-15355 | biostudies-arrayexpress
TranscriptomicsDirect Reprogramming of Fibroblasts into Neural Stem Cells by Defined Factors
Recent advances in the stem cell biology have revealed that cell type-specific transcription factors could reset the somatic memory and induce direct reprogramming into specific cellular identities. The induction of pluripotency in terminally differentiated cells has been a major achievement in the ...
ORGANISM(S): Mus musculus 
2012-05-02 | E-GEOD-30500 | biostudies-arrayexpress
TranscriptomicsGeneration of parthenogenetic iPS cells from parthenogenetic neural stem cell
In pluripotential reprogramming, a pluripotent state is established within somatic cells. In this study, we have generated induced pluripotent stem (iPS) cells from bi-maternal (uniparental) parthenogenetic neural stem cells (pNSCs) by transduction with four (Oct4, Klf4, Sox2, and c-Myc) or two (Oct...
ORGANISM(S): Mus musculus 
2010-05-20 | E-GEOD-15561 | biostudies-arrayexpress
TranscriptomicsReprogramming to pluripotency through a somatic stem cell intermediate
In the past years, transdifferentiation from one lineage to another has become an important research field. In that context, we recently reported the direct reprogramming of mouse embryonic fibroblasts (MEFs) into induced neural stem cells (iNSCs). In this study, we, for the first time, successfully...
ORGANISM(S): Mus musculus 
2014-03-28 | E-GEOD-44284 | biostudies-arrayexpress
ProteomicsProteomics of Duchenne Muscular Dystrophy Patient iPSC - Derived Skeletal Muscle Cells Reveal Differential Expression of Myosin 9, Collagen 18A, Tropomyosin 1, NCAM1, BASP1 and RUVBL1
Proteomics of skeletal muscular dystrophies is limited by the amount of protein which can be provided from patient biopsies. Cells and tissues derived from patient induced pluripotent stem cells (iPSCs) can be an expandable alternative source. We have patterned iPSCs from three Du-chenne Muscular Dy...
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD068000 | Pride
Organoids Patient induced pluripotent stem cells Disease modelling Duchenne muscular dystrophy Proteomics Skeletal muscle 
TranscriptomicsDirect Conversion of Fibroblasts into Oligodendrocyte Progenitor Cells
Many studies have already shown the reprogramming of somatic cells into other cell types such as neural stem cells, blood progenitor cells, and hepatocytes by inducing combinations of transcription factors. One of the recent development in cellular reprogramming is the direct reprogramming, that can...
ORGANISM(S): Mus musculus 
2015-11-02 | E-GEOD-52035 | biostudies-arrayexpress
TranscriptomicsErythroid differentiation of human induced pluripotent stem cells is independent of donor cell type of origin
Epigenetic memory in induced pluripotent stem cells (iPSCs), with regards to their somatic cell type of origin, might lead to variations in their differentiation capacities. In this context, iPSCs from human CD34+ hematopoietic stem cells (HSCs) might be more suitable for hematopoietic differentiati...
ORGANISM(S): Homo sapiens 
2015-02-20 | E-GEOD-55109 | biostudies-arrayexpress
TranscriptomicsSox2 Levels Define Pluripotent Ground States and Reprogramming Potential
Pluripotent stem cell lines derived from embryos of different stages have distinct pluripotent ground states, but similar levels of the transcription factor Oct4. Epiblast-derived pluripotent stem cells (EpiSCs), in contrast to embryonic stem (ES) cells, cannot form chimeras. We show that EpiSCs exp...
ORGANISM(S): Mus musculus 
2010-12-31 | E-GEOD-15358 | biostudies-arrayexpress
TranscriptomicsOrigin-dependent neural cell identities in differentiated human iPS cells in vitro and after transplantation into the rodent brain
The differentiation capability of induced pluripotent stem cells (iPSCs) towards certain cell types for disease modelling and drug screening assays might be influenced by their somatic cell of origin. Here, we have compared the neural induction of human iPSCs generated from either fetal neural stem ...
ORGANISM(S): Homo sapiens 
2014-09-12 | E-GEOD-55107 | biostudies-arrayexpress
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