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ProteomicsChemical damage to mRNA triggers ribosome-based quality control in the cell
Maintaining the integrity of nucleic acids is an essential feature of all organisms. Unwanted modification of DNA, if left unrepaired, is deleterious to cellular homeostasis and could have far-reaching consequences that include genomic instability and accumulation of mutations. Similarly, accumulati...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-11-07 | PXD013834 | Pride
Ubiquitylation Quality control Ribosome collision 
ProteomicsN1-methylpseudouridine found within COVID-19 mRNA vaccines produces faithful protein products
The COVID mRNA vaccines utilize the modified nucleobase N1-methylpseudouridine, in place of canonical uridine, to improve immunogenicity and protein yield. However, relatively few studies have investigated the effect of modified nucleobases on the fidelity of protein translation. Given the interest ...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2022-08-18 | PXD029291 | Pride
Sars-cov-2 N1-methylpseudouridine Ribosome Decoding Fidelity Covid-19 Mrna vaccine Translation 
UnknownGlobal anaesthesia practice using inguinal hernia surgery as a tracer condition: a secondary analysis of an international prospective cohort study.
Not available
S-EPMC12519944 | biostudies-literature
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