Sort   by:  
 Page size 
ProteomicsN1-methylpseudouridine found within COVID-19 mRNA vaccines produces faithful protein products
The COVID mRNA vaccines utilize the modified nucleobase N1-methylpseudouridine, in place of canonical uridine, to improve immunogenicity and protein yield. However, relatively few studies have investigated the effect of modified nucleobases on the fidelity of protein translation. Given the interest ...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2022-08-18 | PXD029291 | Pride
Sars-cov-2 N1-methylpseudouridine Ribosome Decoding Fidelity Covid-19 Mrna vaccine Translation 
GenomicsN1-Methylpseudouridine Directly Modulates Translation Dynamics
N1-Methylpseudouridine Directly Modulates Translation Dynamics
PRJNA1335004 | ENA
GenomicsN1-methylpseudouridine found within COVID-19 mRNA vaccines produces faithful protein products
N1-methylpseudouridine found within COVID-19 mRNA vaccines produces faithful protein products
PRJNA773947 | ENA
ProteomicsN1-Methylpseudouridine and pseudouridine modifications modulate mRNA decoding during translation
Mass spectrometry on affinity-purified luciferase produced from constitutively modified or unmodified mRNA in HEK293 cells.
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD053919 | Pride
N1-methylpseudouridine Ribosome Translation 
OtherN1-methylpseudouridine found within COVID-19 mRNA vaccines produces faithful protein products
Given the interest in the COVID mRNA vaccines, we sought to investigate how the RNA modification N1-methylpseudouridine (and its related modification, pseudouridine) is read by ribosomes and reverse transcriptases. By looking at reverse transcriptase data, we can gain information on how the modifica...
ORGANISM(S): synthetic construct 
2021-10-25 | GSE186464 | GEO
UnknownInfluence of N1-Methylpseudouridine in Guide RNAs on CRISPR/Cas9 Activity.
Not available
S-EPMC10707292 | biostudies-literature
UnknownThe mRNACalc webserver accounts for the N1-methylpseudouridine hypochromicity to enable precise nucleoside-modified mRNA quantification.
Not available
S-EPMC10973171 | biostudies-literature
UnknownModifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines.
Not available
S-EPMC8043204 | biostudies-literature
UnknownN1-Methylpseudouridine and pseudouridine modifications modulate mRNA decoding during translation.
Not available
S-EPMC11405884 | biostudies-literature
TranscriptomicsN1-Methylpseudouridine Directly Modulates Translation Dynamics
The remarkable effectiveness of mRNA vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has highlighted synthetic mRNA as a promising technology. A critical feature of this approach is the incorporation of the modified ribonucleotide N1-methylpseudouridine (m¹Ψ), which enh...
ORGANISM(S): Homo sapiens 
2025-11-09 | GSE309271 | GEO
Sort   by:  
 Page size