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TranscriptomicsTranscription profiling of human ZAP-70+CD38+ and ZAP-70-CD38- B-cells from chronic lymphocytic leukemia patients
B-cell chronic lymphocytic leukemia (B-CLL) is a heterogenous disease with a highly variable clinical course and analysis of ZAP-70 and CD38 expression on B-CLL cells allowed for identification of patients with good (ZAP-70-CD38-), intermediate (discordant expression of ZAP-70 and CD38) and poor (ZA...
ORGANISM(S): Homo sapiens 
2009-04-23 | E-GEOD-4392 | biostudies-arrayexpress
ProteomicsThe zinc finger antiviral protein ZAP destabilises viral transcripts and restricts human cytomegalovirus
Interferon-stimulated gene products (ISGs) play a crucial role in early infection control. The ISG zinc finger CCCH-type antiviral protein 1 (ZAP/ZC3HAV1) antagonises several RNA viruses by binding to CG-rich RNA sequences, whereas its effect on DNA viruses is largely unknown. Here, we decipher the ...
ORGANISM(S): Homo sapiens (Human) 
2021-04-22 | PXD023559 | Pride
Innate immunity Lc-ms/ms Proteomics Isg Antiviral Human cytomegalovirus Zap Interferon 
ProteomicsThe catalytic activity of the kinase Zap-70 mediates basal signaling and negative feedback of the T cell receptor pathway
T cell activation must be properly regulated to ensure normal T cell development and effective immune responses to pathogens and transformed cells, while avoiding autoimmunity. Our knowledge of the mechanisms controlling the fine-tuning of T cell receptor (TCR) signaling and T cell activation is sti...
ORGANISM(S): Homo sapiens (Human) 
2016-05-31 | PXD002023 | Pride
T cell Phosphoproteomics Lc-ms/ms 
GenomicsCLIP-seq for ZAP in HEK293T control and ZAP-L or ZAP-S isoform knockout cells infected with wild type HIV-1 or CpG-recoded HIV-1
CLIP-seq for ZAP in HEK293T control and ZAP-L or ZAP-S isoform knockout cells infected with wild type HIV-1 or CpG-recoded HIV-1
PRJEB88840 | ENA
TranscriptomicsGene expression profile after dexamethasone in chronic lymphocytic leukemia cells according to IGHV/ZAP-70 status
Glucocorticoids are part of the therapeutic armamentarium of chronic lymphocytic leukemia where it has been suggested that cells with unmutated IGHV genes exhibit higher sensitivity. The mechanisms by which glucorticoids are active in CLL are not well elucidated. We used microarrays to detail the gl...
ORGANISM(S): Homo sapiens 
2012-12-04 | E-GEOD-33135 | biostudies-arrayexpress
ProteomicsZAP-70 promotes microenvironment interactions and increases protein-translation in chronic lymphocytic leukemia
The expression of ZAP-70 in a subset of CLL patients strongly correlates with a more aggressive clinical course, though the exact underlying mechanisms remain elusive. The ability of ZAP-70 to enhance B cell receptor (BCR) signaling, independently of its kinase function, likely contributes. Here we ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-26 | PXD019465 | Pride
Zap70 Q-plex_rime Leukemia 
GenomicsCLIP-seq diagram of ZAP-binding RNA mapped to JEV genome
CLIP-seq diagram of ZAP-binding RNA mapped to JEV genome
PRJNA475947 | ENA
GenomicsHIV-2 evolved ZAP resistance despite increased CpG levels
HIV-2 evolved ZAP resistance despite increased CpG levels
PRJNA1228977 | ENA
TranscriptomicsExpression data from native ZAP-70+CD38+ vs. ZAP-70-CD38- CLL cells
B-cell chronic lymphocytic leukemia (B-CLL) is a heterogenous disease with a highly variable clinical course and analysis of ZAP-70 and CD38 expression on B-CLL cells allowed for identification of patients with good (ZAP-70-CD38-), intermediate (discordant expression of ZAP-70 and CD38) and poor (ZA...
ORGANISM(S): Homo sapiens 
2006-09-22 | GSE4392 | GEO
TranscriptomicsExpression of ZAP-70 in CLL activates NF-M-NM-:B signaling
Chronic lymphocytic leukemia (CLL) is a disease with a highly variable prognosis. The clinical course can however be predicted thanks to prognostic markers. Poor prognosis is associated with expression of a B cell receptor (BCR) from unmutated immunoglobulin variable heavy-chain genes (IgVH) and exp...
ORGANISM(S): Homo sapiens 
2013-10-22 | E-GEOD-51286 | biostudies-arrayexpress
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