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TranscriptomicsPeri-alloHCT IL-33 administration expands recipient T regulatory cells that protect mice against acute GvHD
Graft-versus-Host Disease (GvH) is the excessive inflammatory response by mature T cells contained in the graft during bone marrow transplantation. The allogeneic T cells recognize self-antigens as foreign and systemically attack multiple organs mostly with epithelial structures such as the skin, li...
ORGANISM(S): Mus musculus 
2016-06-27 | E-MTAB-4677 | biostudies-arrayexpress
TranscriptomicsAnalysis of mouse T cell transcription profile after co-culture with BaF3 cells with or without the oncogenic point mutation JAK2 V617F
The activation of PD-1 (Programmed Death receptor-1) on T cells can cause T cell exhaustion and immune tolerance. Some tumors up-regulate the expression of the ligand of PD-1, namely PD-L1 (Programmed Death Receptor-Ligand 1), thus preventing anti-tumor immune response and promoting immune-escape. P...
ORGANISM(S): Mus musculus 
2018-12-01 | E-MTAB-5028 | biostudies-arrayexpress
TranscriptomicsLPS & ATP Stimulated wild type and miR-155 KO murine C57BL/6 Dendritic Cells
Dendritic cells isolated from murine bone marrow were cultured for 7 days and then stimulated with 50 ng/mL LPS and 5 mM ATP. Cells derived from both wild type and microRNA-155 knock-out mice. Total RNA was isolated from the cells following stimulation.
ORGANISM(S): Mus musculus 
2015-07-30 | E-MTAB-2608 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of Ba/F3-ITD cells treated with DMSO or sorafenib
The aim of the study is to analyse whether the Sorafenib renders FLT3-ITD-positive acute myeloid leukemia (AML) cells more immunogenic . We used Ba/F3-ITD cells as a model cell line to study the effect of Sorafenib on FLT3-ITD-positive AML cells. Ba/F3-ITD cells are murine pro-B cell lines with a st...
ORGANISM(S): Mus musculus 
2018-02-01 | E-MTAB-4487 | biostudies-arrayexpress
Transcriptomicsallogeneicly stimulated miR-146a-/- versus WT T-cells
The aim of this study was to analyze expression differences between murine splenic miR-146a deficient and miR-146a sufficient T cells after allogeneic stimulation in vitro.
ORGANISM(S): Mus musculus 
2014-12-31 | E-MTAB-2231 | biostudies-arrayexpress
TranscriptomicsLPS-stimulated wildtype and miR-146a KO murine C57BL/6 Bone Marrow-derived Dendritic Cells
Dendritic cells isolated from murine bone marrow were cultured for 7 days and then stimulated with 100 ng/mL LPS for 24h. Cells were derived from either wildtype or microRNA-146a knock-out mice. Total RNA was isolated from the cells following stimulation.
ORGANISM(S): Mus musculus 
2016-07-30 | E-MTAB-3539 | biostudies-arrayexpress
ProteomicsGut-microbiota derived N,N,N-trimethyl-5-aminovaleric acid (TMAVA) is a modulator of CNS-aGVHD
In this study, we report that microbiota depletion results in exacerbated acute graft-vs-host disease in the central nervous system (CNS), mediated by microglia activation and T-cell infiltration. We could rescue the inflammatory changes in the CNS by administering the microbiota-derived metabolite ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-11-14 | MSV000096417 | MassIVE
GenomicsDKFZ-HIPO Project H021/NCT MASTER
Clinical genome and transcriptome sequencing in younger adults with advanced-stage cancer across all histologies: DKFZ-HIPO Project H021 (http://www.hipo-heidelberg.org/hipo2/index.php/menu-item-2/32-021-prospective-genetic-characterization-of-tumors-from-individual-patients-of-special-interest) / N...
EGAS00001000948 | EGA
TranscriptomicsTranscription profiling by array of miRNA in mouse models of melanoma comparing niches of tumour tissue to adjacent normal tissue
This experiment focused on the miRNA expressions within the tissues specific niches of mice afflicted with melanoma, compared to littermates without malignancy. BRafCA/ PtenloxP/ Tyr::CreERT2 or genetically matched littermates without Cre recombinase were treated with 2µl 4-hydroxytamoxifen (5mM), e...
ORGANISM(S): Mus musculus 
2019-01-31 | E-MTAB-6373 | biostudies-arrayexpress
TranscriptomicsExpression via microarray of total RNA isolated from B16 murine melanoma cells stimulated with Interferon-gamma versus untreated controls.
Functional in vitro studies revealed changes in B16 melanoma migration and proliferation when exposed to Interferon-gamma.
ORGANISM(S): Mus musculus 
2019-01-31 | E-MTAB-6372 | biostudies-arrayexpress
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