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ProteomicsQuinoa seed proteome - Characterization of quinoa seed proteome combining different protein precipitation techniques: Improvement of knowledge of nonmodel plant proteomics
A shotgun proteomics approach was used to characterize the quinoa seed proteome. To obtain comprehensive proteomic data from quinoa seeds three different precipitation procedures were employed: MeOH/CHCl3/ddH2O, acetone either alone or with trichloroacetic acid; the isolated proteins were then in-so...
ORGANISM(S): Caryophyllales 
2016-06-24 | PXD001631 | Pride
Plant proteomics High resolution mass spectrometry Quinoa proteins- chenopodium quinoa Non-model plants Protein precipitation 
ProteomicsConvergent evolution of antibiotic resistance mechanisms between synthetic pyrrolobenzodiazepines (PBDs) and the naturally occurring albicidin in multidrug resistant Klebsiella pneumoniae
Klebsiella pneumoniae is designated as one of six priority ESKAPE pathogens by the World Health Organisation (WHO). It is the causative agent of a number of serious infections, including pneumonia, and worryingly strains are known to have resistance to the four major antibiotic classes. Pyrrolobenzo...
ORGANISM(S): Klebsiella pneumoniae subsp. pneumoniae A 
2025-06-16 | PXD059600 | Pride
Multidrug resistance Pyrrolobenzodiazepines (pbds) Klebsiella pneumoniae Gram-negative bacteria Albicidin Antimicrobial resistance 
ProteomicsIn-cell structures of a conserved supramolecular array at the mitochondria-cytoskeleton interface in mammalian sperm
Mitochondria-cytoskeleton interactions modulate cellular physiology by regulating mitochondrial transport, positioning, and immobilization. However, there is very little structural information defining mitochondria-cytoskeleton interfaces in any cell type. Here, we use cryo-focused ion beam milling-...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2021-10-29 | PXD025562 | Pride
Boar sperm Cryo-electron tomography Proteomics Mitochondria Crosslinking 
ProteomicsAdipocyte p53 coordinates the adipose tissue immune cell landscape upon intermittent fasting
In obesity, sustained adipose tissue (AT) inflammation constitutes a cellular memory that limits the effectiveness of weight loss interventions. Yet, its fasting regimen-dependent regulation is unknown. Here, we show that cyclic intermittent fasting (IF) exacerbates the lipid-associated macrophage (...
ORGANISM(S): Homo sapiens (Human) 
2024-01-16 | PXD041351 | Pride
Proteomics Fasting Adipose tissue P53 
ProteomicsSubcellular fractionation of boar spermatozoa provides a novel view of the perinuclear theca proteome
The perinuclear theca (PT) is a highly condensed, largely insoluble protein structure that surrounds the nucleus of eutherian spermatozoa. While this structure is known to be important for fertilization, little is known regarding its proteomic composition. Recent reports have indicated that the PT u...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-03-09 | PXD030020 | Pride
Boar sperm Perinuclear theca proteome Head tail division 
ProteomicsHSF-1 promotes longevity through ubiquilin-1 dependent mitochondrial remodelling
Impaired protein homeostasis promotes age-associated tissue dysregulation, presenting a need for therapeutic approaches that can restore proteome integrity. The heat shock factor HSF-1 is the master transcriptional regulator of proteostasis and regulates the expression of heat shock proteins (HSPs),...
ORGANISM(S): Caenorhabditis elegans 
2024-10-17 | PXD044595 | Pride
Hsf-1  aging  proteomics 
Proteomicsrotein expression in Nav1.7 embryonic null mice – mechanisms of compensation
Mice and humans who have lost the expression of functional sodium channel Nav1.7 are pain-free, but otherwise normal. This is the result of a loss of neurotransmitter release such as glutamate and Substance P from primary sensory neurons. The sensory neurons are otherwise normal apart from loss of n...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD052513 | Pride
Two mechanisms of analgesia Drugs Pain Humans Autonomic side-effects Embryonic and adult nulls Sodium channels Mice Nav1.7 Opioid signalling 
ProteomicsGENOMIC INVESTIGATIONS OF ACUTE HEPATITIS OF UNKNOWN AETIOLOGY IN CHILDREN
Since the first reports of hepatitis of unknown aetiology occurring in UK children, over 1000 cases have been reported worldwide, including 268 cases in the UK, with the majority younger than 6 years old. Using genomic, proteomic and immunohistochemical methods, we undertook extensive investigation ...
ORGANISM(S): Homo sapiens (Human) 
2023-04-04 | PXD035925 | Pride
Proteomics Liver Epatitis Fractionatio 
ProteomicsShotgun proteomic analysis of embryonic axis of soybean seeds during germination under salt stress
Salinity is one of the main environmental stresses worldwide limiting soybean growth and yield. Seed imbibition and radical emergence are generally less affected by salinity in soybean. Towards unraveling the mechanisms underlying salt tolerance in soybean at germination stage, a comprehensive quant...
ORGANISM(S): Glycine Max (ncbitaxon:3847) 
2016-08-15 | MSV000080044 | MassIVE
ProteomicsPharmacoproteomic characterisation of human colon and rectal cancer - CRC65 Full Proteomes
Most molecular cancer therapies act on protein targets but data on the proteome status of patients and cellular models are only beginning to emerge. Here, we profiled the proteomes of 65 colorectal cancer (CRC) cell lines to a depth of >10,000 proteins using mass spectrometry. Integration with prote...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-23 | MSV000081738 | MassIVE
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